Rabbit anti GAB1 (pTyr627) antibody recognizes GRB2-associated-binding protein 1, also known as GAB1, GRB2-associated binder 1 or Growth factor receptor bound protein 2-associated protein 1 when phosphorylated at tyrosine 627. GAB1 is a docking protein capable of interactions with several different proteins particularly the activation of receptor tyrosine kinase signaling. Phosphorylation of GAB1 at tyrosine 627 leads to SHP2 recruitment and subsequent activation of MAPK signaling.
- Target Species
- Species Cross-Reactivity
|Target Species||Cross Reactivity|
||Expected from Sequence
- N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antiserum to GAB1 (pTyr627) was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.02% Sodium Azide
- Phospho specific-peptide corresponding to residues surrounding tyrosine 627 of human GAB1
- Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
SH3/SH2 adaptor activity
epidermal growth factor receptor signaling pathway
insulin receptor signaling pathway
fibroblast growth factor receptor signaling pathway
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of GAB1 (pTyr627) antibody
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
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Secondary Antibodies Available
Useful Reagents Available