Frataxin antibody
Rabbit anti Human frataxin antibody recognizes frataxin, also known as Friedreich ataxia protein, FRDA and FXN.
This nuclear gene encodes a mitochondrial protein thatfunctions in regulating mitochondrial iron transport and respiration. The expansion of intronic trinucleotide repeat GAA results in the autosomal recessive inherited disease Friedreich ataxia. Alternative splicing results in multiple transcript variants (provided by RefSeq, Jun 2009).
Rabbit anti Human frataxin antibody detects a band of 24 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
This nuclear gene encodes a mitochondrial protein thatfunctions in regulating mitochondrial iron transport and respiration. The expansion of intronic trinucleotide repeat GAA results in the autosomal recessive inherited disease Friedreich ataxia. Alternative splicing results in multiple transcript variants (provided by RefSeq, Jun 2009).
Rabbit anti Human frataxin antibody detects a band of 24 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
Product Details
- Target Species
- Human
- Western Blotting
- Anti frataxin antibody recognizes a band of approximately 24 kDa in Raji cell lysates
- Species Cross-Reactivity
-
Target Species Cross Reactivity Mouse - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Preparation
- Rabbit polyclonal antibody purified by affinity chromatography on immunogen
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
2% Sucrose - Immunogen
- Synthetic peptide corresponding to a portion of the C terminal segment of human frataxin
Storage Information
- Storage
- Store undiluted at -20°C, avoiding repeated freeze thaw cycles
- Guarantee
- 12 months from date of despatch
More Information
- UniProt
- Q16595
- Entrez Gene
- FXN
- GO Terms
- GO:0005515 protein binding
- GO:0004322 ferroxidase activity
- GO:0005829 cytosol
- GO:0005759 mitochondrial matrix
- GO:0006783 heme biosynthetic process
- GO:0006826 iron ion transport
- GO:0006879 cellular iron ion homeostasis
- GO:0008198 ferrous iron binding
- GO:0008199 ferric iron binding
- GO:0008284 positive regulation of cell proliferation
- GO:0010039 response to iron ion
- GO:0010722 regulation of ferrochelatase activity
- GO:0016540 protein autoprocessing
- GO:0018283 iron incorporation into metallo-sulfur cluster
- GO:0030307 positive regulation of cell growth
- GO:0034986 iron chaperone activity
- GO:0043066 negative regulation of apoptosis
- GO:0048554 positive regulation of metalloenzyme activity
- GO:0051347 positive regulation of transferase activity
- GO:0051349 positive regulation of lyase activity
- GO:0051353 positive regulation of oxidoreductase activity
- GO:0051537 2 iron, 2 sulfur cluster binding
- GO:0070301 cellular response to hydrogen peroxide
- GO:0090201 negative regulation of release of cytochrome c from mitochondria
- Acknowledgements
- PrecisionAb is a trademark of Bio-Rad Laboratories
- Regulatory
- For research purposes only
Applications of Frataxin antibody
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting | 1/1000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
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Secondary Antibodies Available
| Description | Product Code | Applications | Pack Size | List Price | Quantity |
|---|---|---|---|---|---|
| Goat anti Rabbit IgG (H/L):HRP | STAR208P | WB | 2 ml |
