Frataxin antibody

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Anti Frataxin Antibody (PrecisionAb Polyclonal Antibody) gallery image 1 — Western blot analysis of whole cell lysates probed with frataxin antibody followed by detection with Goat anti Rabbit HRP conjugated (1/10,000, STAR208P) and visualized on the ChemiDoc MP with 30 second exposure. Arrow points to frataxin (molecular weight 24 kDa)

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Rabbit anti Frataxin

Product Type: PrecisionAb Polyclonal
Isotype: Polyclonal IgG
Format: Purified
Specificity: Frataxin

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VPA00877 Datasheet Datasheet SDS SDS	WB	100 µl		Log in	Get Quote
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Rabbit anti Human frataxin antibody recognizes frataxin, also known as Friedreich ataxia protein, FRDA and FXN.

This nuclear gene encodes a mitochondrial protein thatfunctions in regulating mitochondrial iron transport and respiration. The expansion of intronic trinucleotide repeat GAA results in the autosomal recessive inherited disease Friedreich ataxia. Alternative splicing results in multiple transcript variants (provided by RefSeq, Jun 2009).

Rabbit anti Human frataxin antibody detects a band of 24 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.

Target Species: Human
Western Blotting: Anti frataxin antibody recognizes a band of approximately 24 kDa in Raji cell lysates
Species Cross-Reactivity: Target Species Cross Reactivity

Mouse; N.B. Antibody reactivity and working conditions may vary between species.
Product Form: Purified IgG - liquid
Preparation: Rabbit polyclonal antibody purified by affinity chromatography on immunogen
Buffer Solution: Phosphate buffered saline
Preservative Stabilisers: 0.09% Sodium Azide
2% Sucrose
Immunogen: Synthetic peptide corresponding to a portion of the C terminal segment of human frataxin
Regulatory: For research purposes only
Guarantee: 12 months from date of despatch
Acknowledgements: PrecisionAb is a trademark of Bio-Rad Laboratories

Target Species	Cross Reactivity
Mouse

Store undiluted at -20°C, avoiding repeated freeze thaw cycles

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
Western Blotting			1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Description	Product Code	Applications	Pack Size	Your Price
Goat anti Rabbit IgG (H/L):HRP	STAR208P	WB	2 ml	Log in	Get Quote
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Description	Goat anti Rabbit IgG (H/L):HRP

UniProt: Q16595
Entrez Gene: FXN
GO Terms: GO:0005515 protein binding; GO:0004322 ferroxidase activity; GO:0005829 cytosol; GO:0005759 mitochondrial matrix; GO:0006783 heme biosynthetic process; GO:0006826 iron ion transport; GO:0006879 cellular iron ion homeostasis; GO:0008198 ferrous iron binding; GO:0008199 ferric iron binding; View More GO Terms; GO:0008284 positive regulation of cell proliferation; GO:0010039 response to iron ion; GO:0010722 regulation of ferrochelatase activity; GO:0016540 protein autoprocessing; GO:0018283 iron incorporation into metallo-sulfur cluster; GO:0030307 positive regulation of cell growth; GO:0034986 iron chaperone activity; GO:0043066 negative regulation of apoptosis; GO:0048554 positive regulation of metalloenzyme activity; GO:0051347 positive regulation of transferase activity; GO:0051349 positive regulation of lyase activity; GO:0051353 positive regulation of oxidoreductase activity; GO:0051537 2 iron, 2 sulfur cluster binding; GO:0070301 cellular response to hydrogen peroxide; GO:0090201 negative regulation of release of cytochrome c from mitochondria