Fractalkine antibody

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Rabbit anti Human Fractalkine:Biotin

Product Type: Polyclonal Antibody
Isotype: Polyclonal IgG
Specificity: Fractalkine

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References (2)
Applications
Storage Information
Batch/Lot Specific Datasheets

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Rabbit anti Human Fractalkine antibody recognizes human fractalkine, otherwise known as CX3CL1, a 397 amino acid CX3C chemokine which signals through the CX3CR1 receptor and is expressed by various tissues including the brain, testis, lung, heart, kidney, colon and skeletal muscle.

Adhesion of fractalkine to the CX3CR1 receptor triggers the chemotaxis and adhesion of leucocytes, including T cells, monocytes and NK cells and fractalkine is involved in the regulation of brain microglia during neuroinflammatory processes (Sunnemark et al. 2005). CX3CL1 may also play a role in dendritic cell mediated host defense against invading pathogens such as Legionella pneumophila (Kikuchi et al. 2005).

Target Species: Human
Product Form: Purified IgG conjugated to Biotin - lyophilized
Reconstitution: Reconstitute with 0.5 ml sterile PBS containing 0.1% Bovine Serum Albumin.
Antiserum Preparation: Antisera to human fractalkine were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Buffer Solution: Phosphate buffered saline
Preservative Stabilisers: None present
Carrier Free: Yes
Immunogen: Recombinant human fractalkine.
Approx. Protein Concentrations: IgG concentration 0.1 mg/ml
Regulatory: For research purposes only
Guarantee: 12 months from date of despatch

Prior to reconstitution store at -20°C.
After reconstitution store at -20°C.

This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
ELISA		0.15	0.30ug/ml
Western Blotting		0.1	0.2ug/ml

Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.