FOXO4 (pSer197) antibody
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WB P ResetRabbit anti FOXO4 (pSer197)
- Product Type
- Polyclonal Antibody
- Isotype
- Polyclonal IgG
- Specificity
- FOXO4 (pSer197)
Antibody Quality and 
Unrivaled 
| Rabbit anti FOXO4 (pSer197) antibody recognizes FOXO4, when phosphorylated at serine 197. FOXO4 is a member of the forkhead family of transcription factors. Residue 197 of FOXO4 is phosphorylated by a number of kinases including AKT. Phosphorylation of FOXO4 at serine 197 results in decreased transcriptional activity and export of FOXO4 from the nucleus. |
- Target Species
- Human
- Species Cross-Reactivity
-
Target Species Cross Reactivity Mouse Expected from Sequence Rat Expected from Sequence - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antiserum to FOXO4 (pSer197) was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.02% Sodium Azide
50% Glycerol - Immunogen
- Phospho specific-peptide corresponding to residues surrounding serine 197 of human FOXO4
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Immunohistology - Paraffin |  |
1/50 | 1/100 |
| Western Blotting | |
1/500 | 1/2000 |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
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- UniProt
- P98177
- Entrez Gene
- FOXO4
- GO Terms
- GO:0000080 G1 phase of mitotic cell cycle
- GO:0003690 double-stranded DNA binding
- GO:0003704 specific RNA polymerase II transcription factor activity
- GO:0003705 sequence-specific enhancer binding RNA polymerase II transcription factor activity
- GO:0005829 cytosol
- GO:0005667 transcription factor complex
- GO:0007050 cell cycle arrest
- GO:0007095 mitotic cell cycle G2/M transition DNA damage checkpoint
- GO:0009790 embryo development
- View More GO Terms
- GO:0007389 pattern specification process
- GO:0009888 tissue development
- GO:0007517 muscle organ development
- GO:0008134 transcription factor binding
- GO:0008285 negative regulation of cell proliferation
- GO:0008286 insulin receptor signaling pathway
- GO:0008301 DNA bending activity
- GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter
- GO:0010843 promoter binding
- GO:0016525 negative regulation of angiogenesis
- GO:0016563 transcription activator activity
- GO:0016566 specific transcriptional repressor activity
- GO:0019901 protein kinase binding
- GO:0048015 phosphatidylinositol-mediated signaling
- GO:0030154 cell differentiation
- GO:0045944 positive regulation of transcription from RNA polymerase II promoter
- GO:0048011 nerve growth factor receptor signaling pathway
- GO:0051090 regulation of transcription factor activity
- GO:0051151 negative regulation of smooth muscle cell differentiation
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