Focal Adhesion Kinase antibody
FAK plays a potential role in oncogenic transformation, and its expression is thought to be correlated to tumour invasiveness (Ibbetson et al. 2013).
Product Details
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antisera to focal adhesion kinase were raised by repeated immunisations of rabbit with highly purified antigen. Purified IgG prepared by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.1% Sodium Azide (NaN3)
- Immunogen
- Synthetic 16 amino acid peptide for the internal domain of human focal adhesion kinase.
- Approx. Protein Concentrations
- IgG concentration 1.0mg/ml
Storage Information
- Storage
- Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. - Guarantee
- 12 months from date of despatch
More Information
- UniProt
- Q05397
- Entrez Gene
- PTK2
- GO Terms
- GO:0007596 blood coagulation
- GO:0005829 cytosol
- GO:0004715 non-membrane spanning protein tyrosine kinase activity
- GO:0004871 signal transducer activity
- GO:0005524 ATP binding
- GO:0005856 cytoskeleton
- GO:0005925 focal adhesion
- GO:0006468 protein phosphorylation
- GO:0006921 cellular component disassembly involved in apoptosis
- GO:0007172 signal complex assembly
- GO:0007229 integrin-mediated signaling pathway
- GO:0007411 axon guidance
- GO:0042169 SH2 domain binding
- Regulatory
- For research purposes only
Applications of Focal Adhesion Kinase antibody
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
Immunohistology - Paraffin 1 | 2 | 5ug/ml |
- 1This product requires antigen retrieval using heat treatment prior to staining of paraffin sections.Sodium citrate buffer pH 6.0 is recommended for this purpose.
- Histology Positive Control Tissue
- Ductal and lobular epithelium.
Secondary Antibodies Available
Description | Product Code | Applications | Pack Size | List Price | Quantity |
---|---|---|---|---|---|
Goat anti Rabbit IgG (Fc):Biotin | STAR121B | E WB | 1 mg |
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Goat anti Rabbit IgG (Fc):FITC | STAR121F | F | 1 mg |
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Goat anti Rabbit IgG (Fc):HRP | STAR121P | E WB | 1 mg |
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Goat anti Rabbit IgG (H/L):HRP | STAR124P | C E WB | 1 mg |
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Sheep anti Rabbit IgG:FITC | STAR34B | C F | 1 mg |
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Sheep anti Rabbit IgG:RPE | STAR35A | F | 1 ml |
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Sheep anti Rabbit IgG:DyLight®488 | STAR36D488GA | F IF WB | 0.1 mg | ||
Sheep anti Rabbit IgG:DyLight®680 | STAR36D680GA | F IF WB | 0.1 mg | ||
Sheep anti Rabbit IgG:Dylight®800 | STAR36D800GA | F IF WB | 0.1 mg |
Useful Reagents Available
Description | Product Code | Applications | Pack Size | List Price | Quantity |
---|---|---|---|---|---|
Antigen Retrieval Buffer, pH8.0 | BUF025A | P | 500 ml | ||
Antigen Retrieval Buffer, pH8.0 | BUF025C | P | 50 ml |
Product Specific References
References for Focal Adhesion Kinase antibody
-
Mclean, G.W. et al. (2005) The role of focal-adhesion kinase in cancer - a new therapeutic opportunity.
Nat Rev Cancer. 5 (7): 505-15. -
Mitra, S.K. et al. (2005) Focal adhesion kinase: in command and control of cell motility.
Nat Rev Mol Cell Biol. 6 (1): 56-68.
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