FLIP Gamma/Delta antibody

Rabbit anti FLIP Gamma/Delta

Product Type
PrecisionAb Polyclonal
Isotype
Polyclonal IgG
Format
Purified
Specificity
FLIP Gamma/Delta

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VPA00085
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Rabbit anit Human FLIP gamma/delta antibody recognizes the apoptosis related protein designated FLIP (FLICE inhibitory protein) or I-FLICE.

FLIP interacts with the adaptor protein FADD, and with caspase-8 (FLICE) and caspase-10 (FLICE2) to inhibit apoptosis induced by death receptors including CD95, DR3, TRAIL-R and TNFR1.

FLICE inhibitory proteins were initially identified in virus and human and were accordingly designated as v-FLIPs and c-FLIPs. Four spice variants of c-FLIP have been identified and are classified as FLIP alpha, beta, delta and gamma. This antibody recognizes the human delta and gamma variants but not the alpha or beta variants.

FLIP is widely expressed in human tissues. Rabbit anti Human FLIP gamma/delta antibody detects FLIP as a band of 25 kDa in human Jurkat, Ramos and Raji cell line lysates.
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Rabbit anti FLIP gamma/delta detects a band of approximately 25 kDa in Jurkat cell lysates.
Product Form
Purified IgG - liquid
Preparation
Rabbit polyclonal antibody purified by affinity chromatography.
Buffer Solution
Phosphate buffered saline.
Preservative Stabilisers
0.09% Sodium Azide (NaN3).
Immunogen
A peptide corresponding to aa191-209 at the C-terminus of human FLIP.
Regulatory
For research purposes only.
Guarantee
12 months from date of despatch.
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunohistology - Frozen
Western Blotting 1/1000
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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Further Reading

  1. Thome, M. et al. (1997) Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors.
    Nature. 386 (6624): 517-21.
  2. Irmler, M. et al. (1997) Inhibition of death receptor signals by cellular FLIP.
    Nature. 388 (6638): 190-5.
  3. Shu, H.B. et al. (1997) Casper is a FADD- and caspase-related inducer of apoptosis.
    Immunity. 6 (6): 751-63.
  4. Hu, S. et al. (1997) I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1- and CD-95-induced apoptosis.
    J Biol Chem. 272 (28): 17255-7.

Synonyms
I-FLICE
UniProt
O15519
Entrez Gene
CFLAR
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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