FKBP1A antibody

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Anti FKBP1A Antibody (PrecisionAb Polyclonal Antibody) gallery image 1 — Western blot analysis of whole cell lysates probed with Rabbit anti Human FKBP1A antibody (**VPA00601**) followed by detection with HRP conjugated Goat anti Rabbit IgG antibody (1/10,000, STAR208P) and visualized on the ChemiDoc MP with 41 second exposure. Arrow points to FKBP1A (molecular weight 16 kDa).

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Rabbit anti FKBP1A

Product Type: PrecisionAb Polyclonal
Isotype: Polyclonal IgG
Format: Purified
Specificity: FKBP1A

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VPA00601 Datasheet Datasheet SDS SDS	WB	100 µl		Log in	Get Quote
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Rabbit anti Human FKBP1A antibody recognizes the peptidyl-prolyl cis-trans isomerase FKBP1A, also known as 12 kDa FK506-binding protein, 12 kDa FKBP, FKBP12-Exip3, PPIase FKBP1A, calstabin 1, immunophilin FKBP12, protein kinase C inhibitor 2 or rotamase.

The protein encoded by the FKBP1A gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. Multiple alternatively spliced variants, encoding the same protein, have been identified. The human genome contains five pseudogenes related to FKBP1A, at least one of which is transcribed (provided by RefSeq, Sep 2008).

Rabbit anti Human FKBP1A gene antibody detects a band of 16 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.

Target Species: Human
Western Blotting: Anti FKBP1A detects a band of approximately 16 kDa in Raji cell lysates.
Product Form: Purified IgG - liquid.
Preparation: Rabbit polyclonal antibody purified by affinity chromatography.
Buffer Solution: Phosphate buffered saline.
Preservative Stabilisers: 0.09% Sodium Azide (NaN₃)
2% Sucrose.
Immunogen: Synthetic peptide directed towards the middle region of human FKBP1A
Regulatory: For research purposes only.
Guarantee: 12 months from date of despatch.
Acknowledgements: PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
Western Blotting		1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Description	Product Code	Applications	Pack Size	Your Price
Goat anti Rabbit IgG (H/L):HRP	STAR208P	WB	2 ml	Log in	Get Quote
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Description	Goat anti Rabbit IgG (H/L):HRP

UniProt: P62942
Entrez Gene: FKBP1A
GO Terms: GO:0003755 peptidyl-prolyl cis-trans isomerase activity; GO:0042026 protein refolding; GO:0005829 cytosol; GO:0004871 signal transducer activity; GO:0005528 FK506 binding; GO:0006458 'de novo' protein folding; GO:0007183 SMAD protein complex assembly; GO:0014802 terminal cisterna; GO:0022417 protein maturation by protein folding; View More GO Terms; GO:0031398 positive regulation of protein ubiquitination; GO:0032092 positive regulation of protein binding; GO:0032513 negative regulation of protein phosphatase type 2B activity; GO:0032925 regulation of activin receptor signaling pathway; GO:0034205 beta-amyloid formation; GO:0034713 type I transforming growth factor beta receptor binding; GO:0042110 T cell activation; GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade; GO:0043206 fibril organization; GO:0046332 SMAD binding; GO:0048185 activin binding; GO:0050776 regulation of immune response; GO:0055010 ventricular cardiac muscle tissue morphogenesis; GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity; GO:0060347 heart trabecula formation