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Fibrinogen antibody

Sheep anti Human Fibrinogen

Product Type
Polyclonal Antibody
Polyclonal IgG

Product Code Applications Pack Size List Price Your Price Qty
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
C E IF 1 ml loader
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Sheep anti Human fibrinogen antibody recognizes human fibrinogen, a complex ~340 kDa hetero-hexameric (di-trimeric) glycoprotein consisting of 3 pairs of α, β and γ chains linked by a series of 29 disulphide bonds (Henschen et al. 1983). The six chains are arranged in such a way that all the N-Terminal ends adjoin to form a central E domain with two trimeric coiled coil structures connecting to outer D domains. Fibrinogen plays an important role in the coagulation process with the D and E domains interacting via the C-Terminal ends of the α chains during fibrin clot cross-linking.

Sheep anti human fibrinogen antibody shows minimal cross-reactivity with related serum proteins. Fibrinogen has been identified as a ferritin binding protein in the horse (Orino et al. 1993). Sheep anti human fibrinogen antibody has been successfully as a capture reagent for ferritin - anti ferritin IgG complexes in horse plasma to evaluate the antibody response to ferritin by ELISA (Takahashi et al. 2013).

Target Species
Species Cross-Reactivity
Target SpeciesCross Reactivity
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Purified IgG prepared by ion exchange chromatography
Buffer Solution
Glycine buffered saline
Preservative Stabilisers
<0.1% Sodium Azide (NaN3)
<0.1% EACA
<0.01% Benzamidine
Human fibrinogen purified from plasma.
Approx. Protein Concentrations
5.0 mg/ml
For research purposes only
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA 1/5000 1/50000
Immunofluorescence 1/200 1/400
Immunohistology - Frozen
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using the appropriate negative/positive controls.

Description Product Code Applications Pack Size List Price Your Price Quantity
Rabbit anti Sheep IgG (H/L):Biotin 5184-2304 C E F WB 1.5 ml loader
List Price Your Price
Description Rabbit anti Sheep IgG (H/L):Biotin

References for Fibrinogen antibody

  1. Grainger, D.J. et al. (2001) Suppressing Thrombin Generation is Compatible With the Development of Atherosclerosis in Mice
    Thromb Res. 102: 71-80.
  2. Grainger, D.J. et al. (2004) Apolipoprotein E modulates clearance of apoptotic bodies in vitro and in vivo, resulting in a systemic proinflammatory state in apolipoprotein E-deficient mice.
    J Immunol. 173: 6366-75.
  3. Plskova, J. et al. (2004) Quantitative evaluation of the corneal endothelium in the mouse after grafting.
    Br J Ophthalmol. 88: 1209-16.
  4. Brill, A. et al. (2011) von Willebrand factor-mediated platelet adhesion is critical for deep vein thrombosis in mouse models.
    Blood. 117: 1400-7.
  5. Barrera, V. et al. (2011) Host fibrinogen stably bound to hemozoin rapidly activates monocytes via TLR-4 and CD11b/CD18-integrin: a new paradigm of hemozoin action.
    Blood. 117: 5674-82.
  6. Takahashi, K. et al. (2013) The presence of heat-labile factors interfering with binding analysis of fibrinogen with ferritin in horse plasma.
    Acta Vet Scand. 55: 70.
  7. Ozaltin, F. et al. (2013) DGKE variants cause a glomerular microangiopathy that mimics membranoproliferative GN.
    J Am Soc Nephrol. 24: 377-84.
  8. Chien, H.W. et al. (2013) Surface conjugation of zwitterionic polymers to inhibit cell adhesion and protein adsorption.
    Colloids Surf B Biointerfaces. 107: 152-9.
  9. View The Latest Product References
  10. Dmitrieva, N.I. and Burg, M.B. (2014) Secretion of von Willebrand factor by endothelial cells links sodium to hypercoagulability and thrombosis.
    Proc Natl Acad Sci U S A. 111: 6485-90.
  11. Johnsen, D. et al. (2016) Disrupting protein tyrosine phosphatase σ does not prevent sympathetic axonal dieback following myocardial infarction.
    Exp Neurol. 276: 1-4.
  12. Piro, J.R. et al. (2018) Inhibition of 2-AG hydrolysis differentially regulates blood brain barrier permeability after injury.
    J Neuroinflammation. 15 (1): 142.
  13. Huet, F. et al. (2020) Low-dose colchicine prevents sympathetic denervation after myocardial ischemia-reperfusion: a new potential protective mechanism
    Future Science OA. : FSO656.
  14. Sepe, J.J. et al. (2022) Therapeutics That Promote Sympathetic Reinnervation Modulate the Inflammatory Response After Myocardial Infarction.
    JACC Basic Transl Sci. 7 (9): 915-30.

Further Reading

  1. Kamath, S. & Lip, G.Y. (2003) Fibrinogen: biochemistry, epidemiology and determinants.
    QJM. 96 (10): 711-29.
  2. Mosesson, M.W. (2005) Fibrinogen and fibrin structure and functions.
    J Thromb Haemost. 3 (8): 1894-904.


Entrez Gene
GO Terms
GO:0002576 platelet degranulation
GO:0030674 protein binding, bridging
GO:0005102 receptor binding
GO:0007165 signal transduction
GO:0005577 fibrinogen complex
GO:0009897 external side of plasma membrane
GO:0030168 platelet activation
GO:0031093 platelet alpha granule lumen
GO:0043499 eukaryotic cell surface binding
GO:0051258 protein polymerization
GO:0051592 response to calcium ion
GO:0051087 chaperone binding
GO:0005625 soluble fraction


151063 155034

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