FGR is a member of the Src family of protein tyrosine kinases (PTKs). The FGR gene encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of FGR. Multiple alternatively spliced variants, encoding the same protein, have been identified (provided by RefSeq, Jul 2008).
Rabbit anti Human FGR antibody detects a band of 56 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
- Target Species
- Western Blotting
- Anti FGR detects a band of approximately 56 kDa in Ramos cell lysate
- Product Form
- Ig fraction - liquid
- Rabbit Ig fraction prepared by ammonium sulphate precipitation
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- KLH-conjugated synthetic peptide corresponding to aa 3-33 of human FGR
- Store undiluted at -20oC, avoiding repeated freeze thaw cycles
- As supplied, 12 months from date of despatch
- P09769 Related reagents
- Entrez Gene
- FGR Related reagents
- GO Terms
- GO:0009615 response to virus
- GO:0005829 cytosol
- GO:0004715 non-membrane spanning protein tyrosine kinase activity
- GO:0005524 ATP binding
- GO:0006468 protein phosphorylation
- GO:0030168 platelet activation
- PrecisionAb is a trademark of Bio-Rad Laboratories.
- For research purposes only
Applications of FGR antibody
|Application Name||Verified||Min Dilution||Max Dilution|
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
Secondary Antibodies Available
|Description||Product Code||Applications||Pack Size||List Price||Quantity|
|Goat anti Rabbit IgG (H/L):HRP||STAR208P||WB||2 ml|
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