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|Rabbit anti Human FGFR2 antibody recognizes fibroblast growth factor receptor 2 (FGFR2), alos known as BEK fibroblast growth factor receptor, keratinocyte growth factor receptor or CD332.
The protein encoded by the FGFR2 gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in FGFR2 are associated with many forms of Craniosynostosis, including Crouzon syndrome (CS), Pfeiffer syndrome (PS), Apert syndrome (APRS), Jackson-Weiss syndrome (JWS), Beare-Stevenson cutis gyrata syndrome (BSTVS), Saethre-Chotzen syndrome (SCS), and Familial scaphocephaly syndrome (FSPC). Multiple alternatively spliced transcript variants encoding different isoforms have been noted for FGFR2 (provided by RefSeq, Jan 2009).
Rabbit anti Human FGFR2 antibody detects a band of 92 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
- Target Species
- Western Blotting
- Anti FGFR2 detects a band of approximately 92 kDa in Jurkat cell lysates.
- Product Form
- Purified IgG - liquid.
- Rabbit polyclonal antibody purified by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline.
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Synthetic peptide directed towards the C terminal region of human FGFR2
- For research purposes only.
- 12 months from date of despatch.
- PrecisionAb is a trademark of Bio-Rad Laboratories.
|Application Name||Verified||Min Dilution||Max Dilution|
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