FGFR2 antibody

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Rabbit anti FGFR2

Product Type
PrecisionAb Polyclonal
Isotype
Polyclonal IgG
Format
Purified
Product Code Applications Pack Size List Price Quantity
VPA00476
Datasheet
WB
MSDS
100 µl loader

Rabbit anti Human FGFR2 antibody recognizes fibroblast growth factor receptor 2 (FGFR2), alos known as BEK fibroblast growth factor receptor, keratinocyte growth factor receptor or CD332.

The protein encoded by the FGFR2 gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in FGFR2 are associated with many forms of Craniosynostosis, including Crouzon syndrome (CS), Pfeiffer syndrome (PS), Apert syndrome (APRS), Jackson-Weiss syndrome (JWS), Beare-Stevenson cutis gyrata syndrome (BSTVS), Saethre-Chotzen syndrome (SCS), and Familial scaphocephaly syndrome (FSPC). Multiple alternatively spliced transcript variants encoding different isoforms have been noted for FGFR2 (provided by RefSeq, Jan 2009).

Rabbit anti Human FGFR2 antibody detects a band of 92 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.

Product Details

Target Species
Human
Western Blotting
Anti FGFR2 detects a band of approximately 92 kDa in Jurkat cell lysates.
Product Form
Purified IgG - liquid.
Preparation
Rabbit polyclonal antibody purified by affinity chromatography.
Buffer Solution
Phosphate buffered saline.
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
2% Sucrose.
Immunogen
Synthetic peptide directed towards the C terminal region of human FGFR2

Storage Information

Storage
Store undiluted at -20°C, avoiding repeated freeze thaw cycles.
Guarantee
12 months from date of despatch

More Information

UniProt
P21802
Entrez Gene
FGFR2
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories
Regulatory
For research purposes only.

Applications of FGFR2 antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Secondary Antibodies Available

Description Product Code Applications Pack Size List Price Quantity
Goat anti Rabbit IgG (H/L):HRP STAR208P WB 2 ml