FGFR2 antibody

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Anti FGFR2 Antibody (PrecisionAb Polyclonal Antibody) gallery image 1 — Western blot analysis of whole cell lysates probed with FGFR2 antibody followed by detection with HRP conjugated Goat anti Rabbit IgG antibody (1/10,000, STAR208P) and visualized on the ChemiDoc MP with 7 second exposure. Arrow points to FGFR2 (molecular weight 92 kDa).

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Rabbit anti FGFR2

Product Type: PrecisionAb Polyclonal
Isotype: Polyclonal IgG
Format: Purified
Specificity: FGFR2

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Rabbit anti Human FGFR2 antibody recognizes fibroblast growth factor receptor 2 (FGFR2), alos known as BEK fibroblast growth factor receptor, keratinocyte growth factor receptor or CD332.

The protein encoded by the FGFR2 gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in FGFR2 are associated with many forms of Craniosynostosis, including Crouzon syndrome (CS), Pfeiffer syndrome (PS), Apert syndrome (APRS), Jackson-Weiss syndrome (JWS), Beare-Stevenson cutis gyrata syndrome (BSTVS), Saethre-Chotzen syndrome (SCS), and Familial scaphocephaly syndrome (FSPC). Multiple alternatively spliced transcript variants encoding different isoforms have been noted for FGFR2 (provided by RefSeq, Jan 2009).

Rabbit anti Human FGFR2 antibody detects a band of 92 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.

Target Species: Human
Western Blotting: Anti FGFR2 detects a band of approximately 92 kDa in Jurkat cell lysates.
Product Form: Purified IgG - liquid.
Preparation: Rabbit polyclonal antibody purified by affinity chromatography.
Buffer Solution: Phosphate buffered saline.
Preservative Stabilisers: 0.09% Sodium Azide (NaN₃)
2% Sucrose.
Immunogen: Synthetic peptide directed towards the C terminal region of human FGFR2
Regulatory: For research purposes only.
Guarantee: 12 months from date of despatch.
Acknowledgements: PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
Western Blotting		1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.