Goat anti Human FGF 10 antibody
recognizes human FGF 10 (fibroblast growth factor 10), a member of the heparin-binding growth factors family which act as promoters of cellular differentiation and proliferation, and therefore play key roles in embryonic development, morphogenesis, tissue regeneration and tumour growth and invasion.
FGF 10 signals through binding to the FGF Receptor (FGFR) 2b, and has structural and biological activities similar to that of FGF 7. Defects in FGF 10 are responsible for the autosomal dominant disorders known as lacrimo-auriculo-dento-digital syndrome (LADDS
), and aplasia of lacrimal and salivary glands (ALSG
- Target Species
- Product Form
- Purified IgG - lyophilised
- Reconstitute with 0.1ml distilled water
Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. Bio-Rad recommend that the vial is gently mixed after reconstitution. For long term storage the addition of 0.09% sodium azide is recommended.
- Antiserum Preparation
- Antiserum to human FGF 10 were raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- None present
- Recombinant human FGF 10
- Approx. Protein Concentrations
- IgG concentration 1.0mg/ml after reconstitution
- Prior to reconstitution store at -20oC.
After reconstitution store at -20oC.
Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- Guaranteed for 3 months from the date of reconstitution or until the date of expiry, whichever comes first. Please see label for expiry date.
- Entrez Gene
- GO Terms
activation of MAPK activity
type 2 fibroblast growth factor receptor binding
growth factor activity
insulin receptor signaling pathway
positive regulation of epithelial cell migration
positive regulation of keratinocyte proliferation
transcription activator activity
actin cytoskeleton reorganization
positive regulation of cyclin-dependent protein kinase activity involved in G1/S
positive regulation of ATPase activity
lacrimal gland development
protein localization at cell surface
positive regulation of DNA repair
positive regulation of DNA replication
positive regulation of Ras protein signal transduction
regulation of saliva secretion
positive regulation of lymphocyte proliferation
urothelial cell proliferation
positive regulation of urothelial cell proliferation
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of keratinocyte migration
response to protein stimulus
radial glial cell differentiation
positive regulation of epithelial cell proliferation involved in wound healing
lung saccule development
bud outgrowth involved in lung branching
fibroblast growth factor receptor signaling pathway involved in mammary gland specification
secretion by lung epithelial cell involved in lung growth
ERK1 and ERK2 cascade
positive regulation of ERK1 and ERK2 cascade
negative regulation of cell cycle arrest
positive regulation of hair follicle cell proliferation
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of FGF 10 antibody
|Immunohistology - Paraffin 1
- 1This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose.
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
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Secondary Antibodies Available
Useful Reagents Available