FCP1 antibody

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Rabbit anti FCP1

Product Type
PrecisionAb Polyclonal
Isotype
Polyclonal IgG
Format
Purified
Product Code Applications Pack Size List Price Quantity
VPA00440
Datasheet
WB
MSDS
100 µl loader

Rabbit anti Human FCP1 antibody recognizes FCP1, also known as RNA polymerase II subunit A C-terminal domain phosphatase, serine phosphatase FCP1a or transcription factor IIF-associating CTD phosphatase 1.

The CTDP1 gene encodes a protein which interacts with the carboxy-terminus of the RAP74 subunit of transcription initiation factor TFIIF, and functions as a phosphatase that progressively dephosphorylates the C-terminus of POLR2A (a subunit of RNA polymerase II), making it available for initiation of gene expression. Mutations in CTDP1 are associated with "congenital cataracts, facial dysmorphism and neuropathy syndrome" (CCFDN). Alternatively spliced transcript variants encoding different isoforms have been described for CTDP1 (provided by RefSeq, Feb 2011).

Rabbit anti Human FCP1 antibody detects a band of 104 kDa and has been extensively validated for western blotting using whole cell lysates.

Product Details

Target Species
Human
Western Blotting
Anti FCP1 detects a band of approximately 104 kDa in HEK293 cell lysates.
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid.
Preparation
Rabbit polyclonal antibody purified by affinity chromatography.
Buffer Solution
Phosphate buffered saline.
Preservative Stabilisers
0.09% Sodium Azide (NaN3).
Immunogen
KLH conjugated synthetic peptide corresponding to amino acid 247-276 of human FCP1

Storage Information

Storage
Store undiluted at -20°C, avoiding repeated freeze thaw cycles.
Guarantee
12 months from date of despatch

More Information

UniProt
Q9Y5B0
Entrez Gene
CTDP1
GO Terms
GO:0003899 DNA-directed RNA polymerase activity
GO:0005654 nucleoplasm
GO:0006368 transcription elongation from RNA polymerase II promoter
GO:0006470 protein dephosphorylation
GO:0008420 CTD phosphatase activity
GO:0016032 viral reproduction
GO:0050434 positive regulation of viral transcription
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories
Regulatory
For research purposes only.

Applications of FCP1 antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Secondary Antibodies Available

Description Product Code Applications Pack Size List Price Quantity
Goat anti Rabbit IgG (H/L):HRP STAR208P WB 2 ml