Exodus-2 antibody

Rabbit anti Human Exodus-2:Biotin
- Product Type
- Polyclonal Antibody
- Isotype
- Polyclonal IgG
- Specificity
- Exodus-2
Rabbit anti Human Exodus-2 antibody recognizes human Exodus-2, otherwise known as CCL21, a 111 amino acid CC chemokine which, like CCL19 (small inducible cytokine A19), signals through the CCR7 receptor. Exodus-2 is expressed in the HEV and T cell rich areas of lymph nodes and Peyer’s patches, T cell areas of the spleen and by lymphatic endothelium of many organs, acting as a potent chemoattractant for thymocytes and T lymphocytes. Exodus-2 possesses characteristics of a homing molecule for lymphocytes to secondary lymphoid organs and has been shown to inhibit haematopoiesis. |
- Target Species
- Human
- Product Form
- Purified IgG conjugated to Biotin - lyophilized
- Reconstitution
- Reconstitute with 0.5 ml sterile PBS containing 0.1% Bovine Serum Albumin.
Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. Bio-Rad recommend that the vial is gently mixed after reconstitution.
For long term storage the addition of 0.09% sodium azide is recommended. - Antiserum Preparation
- Antisera to human Exodus-2 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- None present
- Carrier Free
- Yes
- Immunogen
- Recombinant human Exodus-2.
- Approx. Protein Concentrations
- IgG concentration 0.1 mg/ml after reconstitution
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
After reconstitution store at -20°C.
This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
ELISA | ![]() |
0.15 | 0.30ug/ml |
Western Blotting | ![]() |
0.1 | 0.2ug/ml |
References for Exodus-2 antibody
-
Hromas, R. et al. (1997) Isolation and characterization of Exodus-2, a novel C-C chemokine with a unique 37-amino acid carboxyl-terminal extension.
J Immunol. 159 (6): 2554-8. -
Gunn, M.D. et al. (1998) A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes.
Proc Natl Acad Sci U S A. 95 (1): 258-63.
- Synonyms
- CCL21
- RRID
- AB_2071918
- UniProt
- O00585
- Entrez Gene
- CCL21
- GO Terms
- GO:0007165 signal transduction
- GO:0005615 extracellular space
- GO:0006935 chemotaxis
- GO:0006954 inflammatory response
- GO:0006955 immune response
- GO:0007267 cell-cell signaling
- GO:0008009 chemokine activity
Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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