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Exodus-2 antibody

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Rabbit anti Human Exodus-2:Biotin

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
Exodus-2

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Rabbit anti Human Exodus-2 antibody recognizes human Exodus-2, otherwise known as CCL21, a 111 amino acid CC chemokine which, like CCL19 (small inducible cytokine A19), signals through the CCR7 receptor.

Exodus-2 is expressed in the HEV and T cell rich areas of lymph nodes and Peyer’s patches, T cell areas of the spleen and by lymphatic endothelium of many organs, acting as a potent chemoattractant for thymocytes and T lymphocytes. Exodus-2 possesses characteristics of a homing molecule for lymphocytes to secondary lymphoid organs and has been shown to inhibit haematopoiesis.

Target Species
Human
Product Form
Purified IgG conjugated to Biotin - lyophilized
Reconstitution
Reconstitute with 0.5 ml sterile PBS containing 0.1% Bovine Serum Albumin.
Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. Bio-Rad recommend that the vial is gently mixed after reconstitution.
For long term storage the addition of 0.09% sodium azide is recommended.
Antiserum Preparation
Antisera to human Exodus-2 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
None present
Carrier Free
Yes
Immunogen
Recombinant human Exodus-2.
Approx. Protein Concentrations
IgG concentration 0.1 mg/ml after reconstitution
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

Prior to reconstitution store at -20°C.
After reconstitution store at -20°C.

This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA 0.15 0.30ug/ml
Western Blotting 0.1 0.2ug/ml
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

References for Exodus-2 antibody

  1. Hromas, R. et al. (1997) Isolation and characterization of Exodus-2, a novel C-C chemokine with a unique 37-amino acid carboxyl-terminal extension.
    J Immunol. 159 (6): 2554-8.
  2. Gunn, M.D. et al. (1998) A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes.
    Proc Natl Acad Sci U S A. 95 (1): 258-63.

Synonyms
CCL21
RRID
AB_2071918
UniProt
O00585
Entrez Gene
CCL21
GO Terms
GO:0007165 signal transduction
GO:0005615 extracellular space
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007267 cell-cell signaling
GO:0008009 chemokine activity
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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