ERLIN-2 antibody
Rabbit anti ERLIN-2
Rabbit anti-human Erlin-2 antibody recognizes Erlin-2, also known as SPFH domain family, member 2, endoplasmic reticulum lipid raft-associated protein 2 or stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2.
- Product Type
- PrecisionAb™ Polyclonal
- Isotype
- Polyclonal IgG
- Format
- Purified
| Product Code | Applications | Datasheet | MSDS | Pack Size | List Price | Quantity |
|---|---|---|---|---|---|---|
| VPA00592 | WB | 100 µl |
Rabbit anti Human erlin-2 antibody recognizes erlin-2, also known as SPFH domain family, member 2, endoplasmic reticulum lipid raft-associated protein 2 or stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2.
The ERLIN2 gene encodes a member of the SPFH domain-containing family of lipid raft-associated proteins. The encoded protein is a 339 amino acid ~43 kDa single pass type II transmembrane protein localized to lipid rafts of the endoplasmic reticulum membrane and plays a critical role in inositol 1,4,5-trisphosphate (IP3) signaling by mediating ER-associated degradation of activated IP3 receptors. Mutations in ERLIN2 are a cause of Spastic paraplegia 18, autosomal recessive (SPG18). Alternatively spliced transcript variants encoding multiple isoforms have been observed for ERLIN2 (provided by RefSeq, Feb 2012).
Rabbit anti Human erlin-2 antibody detects a band of 43 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
The ERLIN2 gene encodes a member of the SPFH domain-containing family of lipid raft-associated proteins. The encoded protein is a 339 amino acid ~43 kDa single pass type II transmembrane protein localized to lipid rafts of the endoplasmic reticulum membrane and plays a critical role in inositol 1,4,5-trisphosphate (IP3) signaling by mediating ER-associated degradation of activated IP3 receptors. Mutations in ERLIN2 are a cause of Spastic paraplegia 18, autosomal recessive (SPG18). Alternatively spliced transcript variants encoding multiple isoforms have been observed for ERLIN2 (provided by RefSeq, Feb 2012).
Rabbit anti Human erlin-2 antibody detects a band of 43 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
Product Details
- Target Species
- Human
- Western Blotting
- Anti erlin-2 detects a band of approximately 43 kDa in HEK293 cell lysates.
- Product Form
- Purified IgG - liquid.
- Preparation
- Rabbit polyclonal antibody purified by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline.
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
2% Sucrose. - Immunogen
- Synthetic peptide directed towards the middle region of human erlin-2
- Instructions For Use
- Please refer to the PrecisionAb western blotting protocol.
Storage Information
- Storage
- Store undiluted at -20°C, avoiding repeated freeze thaw cycles.
- Guarantee
- As supplied, 12 months from date of despatch.
More Information
- UniProt
- O94905 Related reagents
- Entrez Gene
- ERLIN2 Related reagents
- GO Terms
- GO:0005886 plasma membrane
- GO:0005515 protein binding
- GO:0016021 integral to membrane
- GO:0005789 endoplasmic reticulum membrane
- GO:0030433 ER-associated protein catabolic process
- Acknowledgements
- PrecisionAb™ is a trademark of Bio-Rad Laboratories.
- Regulatory
- For research purposes only.
Applications of ERLIN-2 antibody
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting | 1/1000 |
PrecisionAb antibodies have been extensively validated for the western blot application. The antibody has been validated at the suggested dilution. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependant on sample type.
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| Description | Product Code | Pack Size | Applications | List Price | Quantity |
|---|---|---|---|---|---|
| Goat anti Rabbit IgG (H/L):HRP | STAR208P | 2 ml | WB |
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