ERLIN-2 antibody

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Rabbit anti ERLIN-2

Product Type
PrecisionAb Polyclonal
Isotype
Polyclonal IgG
Format
Purified
Product Code Applications Pack Size List Price Quantity
VPA00592
Datasheet
WB
SDS
100 µl loader

Rabbit anti Human erlin-2 antibody recognizes erlin-2, also known as SPFH domain family, member 2, endoplasmic reticulum lipid raft-associated protein 2 or stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2.

The ERLIN2 gene encodes a member of the SPFH domain-containing family of lipid raft-associated proteins. The encoded protein is a 339 amino acid ~43 kDa single pass type II transmembrane protein localized to lipid rafts of the endoplasmic reticulum membrane and plays a critical role in inositol 1,4,5-trisphosphate (IP3) signaling by mediating ER-associated degradation of activated IP3 receptors. Mutations in ERLIN2 are a cause of Spastic paraplegia 18, autosomal recessive (SPG18). Alternatively spliced transcript variants encoding multiple isoforms have been observed for ERLIN2 (provided by RefSeq, Feb 2012).

Rabbit anti Human erlin-2 antibody detects a band of 43 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.

Product Details

Target Species
Human
Western Blotting
Anti erlin-2 detects a band of approximately 43 kDa in HEK293 cell lysates.
Product Form
Purified IgG - liquid.
Preparation
Rabbit polyclonal antibody purified by affinity chromatography.
Buffer Solution
Phosphate buffered saline.
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
2% Sucrose.
Immunogen
Synthetic peptide directed towards the middle region of human erlin-2

Storage Information

Storage
Store undiluted at -20°C, avoiding repeated freeze thaw cycles.
Guarantee
12 months from date of despatch

More Information

UniProt
O94905
Entrez Gene
ERLIN2
GO Terms
GO:0005886 plasma membrane
GO:0005515 protein binding
GO:0016021 integral to membrane
GO:0005789 endoplasmic reticulum membrane
GO:0030433 ER-associated protein catabolic process
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories
Regulatory
For research purposes only.

Applications of ERLIN-2 antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Secondary Antibodies Available

Description Product Code Applications Pack Size List Price Quantity
Goat anti Rabbit IgG (H/L):HRP STAR208P WB 2 ml