ERLIN-2 antibody

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Anti ERLIN-2 Antibody (PrecisionAb Polyclonal Antibody) gallery image 1 — Western blot analysis of whole cell lysates probed with erlin-2 antibody followed by detection with HRP conjugated Goat anti Rabbit IgG antibody (1/10,000, STAR208P) and visualized on the ChemiDoc MP with 23 second exposure. Arrow points to erlin-2 (molecular weight 43 kDa).

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Rabbit anti ERLIN-2

Product Type: PrecisionAb Polyclonal
Isotype: Polyclonal IgG
Format: Purified
Specificity: ERLIN-2

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VPA00592 Datasheet Datasheet SDS SDS	WB	100 µl		Log in	Get Quote
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Rabbit anti Human erlin-2 antibody recognizes erlin-2, also known as SPFH domain family, member 2, endoplasmic reticulum lipid raft-associated protein 2 or stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2.

The ERLIN2 gene encodes a member of the SPFH domain-containing family of lipid raft-associated proteins. The encoded protein is a 339 amino acid ~43 kDa single pass type II transmembrane protein localized to lipid rafts of the endoplasmic reticulum membrane and plays a critical role in inositol 1,4,5-trisphosphate (IP3) signaling by mediating ER-associated degradation of activated IP3 receptors. Mutations in ERLIN2 are a cause of Spastic paraplegia 18, autosomal recessive (SPG18). Alternatively spliced transcript variants encoding multiple isoforms have been observed for ERLIN2 (provided by RefSeq, Feb 2012).

Rabbit anti Human erlin-2 antibody detects a band of 43 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.

Target Species: Human
Western Blotting: Anti erlin-2 detects a band of approximately 43 kDa in HEK293 cell lysates.
Product Form: Purified IgG - liquid.
Preparation: Rabbit polyclonal antibody purified by affinity chromatography.
Buffer Solution: Phosphate buffered saline.
Preservative Stabilisers: 0.09% Sodium Azide (NaN₃)
2% Sucrose.
Immunogen: Synthetic peptide directed towards the middle region of human erlin-2
Regulatory: For research purposes only.
Guarantee: 12 months from date of despatch
Acknowledgements: PrecisionAb is a trademark of Bio-Rad Laboratories

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
Western Blotting		1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Description	Product Code	Applications	Pack Size	Your Price
Goat anti Rabbit IgG (H/L):HRP	STAR208P	WB	2 ml	Log in	Get Quote
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Description	Goat anti Rabbit IgG (H/L):HRP

UniProt: O94905
Entrez Gene: ERLIN2
GO Terms: GO:0005886 plasma membrane; GO:0005515 protein binding; GO:0016021 integral to membrane; GO:0005789 endoplasmic reticulum membrane; GO:0030433 ER-associated protein catabolic process