Rabbit anti ErbB4 (pTyr1284) antibody
recognizes ErbB4, also known as receptor tyrosine-protein kinase erbB-4 or tyrosine kinase-type cell surface receptor HER4, when phosphorylated at tyrosine 1284.
ErbB4 is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases and plays a key role in the regulation of the nervous system, heart and mammary gland. Tyrosine 1284 of ErbB4 has been identified as a phosphorylation site (Kaushansky et al. 2008
- Target Species
- Species Cross-Reactivity
|Target Species||Cross Reactivity|
||Expected from Sequence
||Expected from Sequence
- N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antiserum to ErbB4 (pTyr1284) was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.02% Sodium Azide
- Phospho specific-peptide corresponding to residues surrounding tyrosine 1284 of human ErbB4
- Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
integral to membrane
transmembrane receptor protein tyrosine kinase activity
receptor signaling protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase signaling pathway
basolateral plasma membrane
regulation of transcription
- PrecisionAb is a trademark of Bio-Rad Laboratories
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of ErbB4 (pTyr1284) antibody
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range.
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
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Secondary Antibodies Available
Useful Reagents Available
Product Specific References
Kaushansky, A. et al. (2008) System-wide investigation of ErbB4 reveals 19 sites of Tyr phosphorylation that are unusually selective in their recruitment properties.
Chem Biol. 15 (8): 808-17.