ErbB4 (pTyr1284) antibody

Rabbit anti ErbB4 (pTyr1284)

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Format
Purified
Specificity
ErbB4 (pTyr1284)

Product Code Applications Pack Size List Price Your Price Qty
AHP2605
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
WB 50 µl loader
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loader
Search for Batch Specific Datasheets

Rabbit anti ErbB4 (pTyr1284) antibody recognizes ErbB4, also known as receptor tyrosine-protein kinase erbB-4 or tyrosine kinase-type cell surface receptor HER4, when phosphorylated at tyrosine 1284.

ErbB4 is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases and plays a key role in the regulation of the nervous system, heart and mammary gland. Tyrosine 1284 of ErbB4 has been identified as a phosphorylation site (Kaushansky et al. 2008).
PrecisionAb Antibodies

Target Species
Human
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse Expected from Sequence
Rat Expected from Sequence
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Antiserum Preparation
Antiserum to ErbB4 (pTyr1284) was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.02% Sodium Azide
50% Glycerol
Immunogen
Phospho specific-peptide corresponding to residues surrounding tyrosine 1284 of human ErbB4
Regulatory
For research purposes only
Guarantee
12 months from date of despatch
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories

Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/500 1/2000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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Further Reading

  1. Kaushansky, A. et al. (2008) System-wide investigation of ErbB4 reveals 19 sites of Tyr phosphorylation that are unusually selective in their recruitment properties.
    Chem Biol. 15 (8): 808-17.

UniProt
Q15303
Entrez Gene
ERBB4
GO Terms
GO:0005515 protein binding
GO:0016021 integral to membrane
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 receptor signaling protein tyrosine kinase activity
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0006350 transcription
GO:0006468 protein phosphorylation
GO:0008283 cell proliferation
GO:0016323 basolateral plasma membrane
GO:0045449 regulation of transcription
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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