ErbB3 (pTyr1328) antibody
Learn more about TPN Total Protein Normalization.
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WB ResetRabbit anti ErbB3 (pTyr1328)
- Product Type
- Polyclonal Antibody
- Isotype
- Polyclonal IgG
- Format
- Purified
- Specificity
- ErbB3 (pTyr1328)
Antibody Quality and 
Unrivaled 
| Rabbit anti ErbB3 (pTyr1328) antibody recognizes ErbB3, also known as receptor tyrosine-protein kinase erbB-3 or tyrosine kinase-type cell surface receptor HER3, when phosphorylated at tyrosine 1328. ErbB3 is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases and plays a key role in cell proliferation and differentiation. ErbB3 acts as a receptor for neuregulins and heterodimerizes with ErbB2. ErbB3 contains a phosphorylation site at tyrosine 1328 (Tzouros et al. 2013). |
|
- Target Species
- Human
- Species Cross-Reactivity
-
Target Species Cross Reactivity Mouse Expected from Sequence Rat Expected from Sequence - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antiserum to ErbB3 (pTyr1328) was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.02% Sodium Azide
50% Glycerol - Immunogen
- Phospho specific-peptide corresponding to residues surrounding tyrosine 1328 of human ErbB3
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
- Acknowledgements
- PrecisionAb is a trademark of Bio-Rad Laboratories
Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting |  |
1/500 | 1/1000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
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Further Reading
-
Tzouros, M. et al. (2013) Development of a 5-plex SILAC method tuned for the quantitation of tyrosine phosphorylation dynamics.
Mol Cell Proteomics. 12 (11): 3339-49.
- UniProt
- P21860
- Entrez Gene
- ERBB3
- GO Terms
- GO:0004714 transmembrane receptor protein tyrosine kinase activity
- GO:0004716 receptor signaling protein tyrosine kinase activity
- GO:0019838 growth factor binding
- GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
- GO:0005887 integral to plasma membrane
- GO:0005524 ATP binding
- GO:0005615 extracellular space
- GO:0006468 protein phosphorylation
- GO:0007162 negative regulation of cell adhesion
- View More GO Terms
- GO:0007507 heart development
- GO:0009968 negative regulation of signal transduction
- GO:0014037 Schwann cell differentiation
- GO:0014065 phosphatidylinositol 3-kinase cascade
- GO:0014068 positive regulation of phosphatidylinositol 3-kinase cascade
- GO:0016323 basolateral plasma membrane
- GO:0021545 cranial nerve development
- GO:0030296 protein tyrosine kinase activator activity
- GO:0042060 wound healing
- GO:0042127 regulation of cell proliferation
- GO:0042803 protein homodimerization activity
- GO:0043235 receptor complex
- GO:0043524 negative regulation of neuron apoptosis
- GO:0046982 protein heterodimerization activity
- GO:0051048 negative regulation of secretion
- GO:0051402 neuron apoptosis
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