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EGR1 antibody

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Staining of formalin fixed, paraffin embedded human lung small cell carcinoma with Rabbit anti Human EGR1 (AHP1939),

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Rabbit anti EGR1

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
EGR1

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Technical Suppport
Product Code Applications Pack Size List Price Your Price Qty
AHP1939
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E P * WB 50 µg loader
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Rabbit anti EGR1 antibody recognizes human Early Growth Response Protein 1. EGR1 is a ~58 kDa nuclear protein belonging to the EGR family of C2H2-type zinc-finger proteins.

EGR1 functions as a transcriptional regulator. The products of target genes it activates are required for differentiation and mitogenesis. Research has also demonstrated that EGR1 expression is elevated in a range of cancers including prostate cancer where EGR1 has been shown to promote the growth of tumor cells.

Target Species
Human
Species Cross-Reactivity
Target SpeciesCross Reactivity
Bovine Expected from Sequence
Chimpanzee Expected from Sequence
Dog Expected from Sequence
Rhesus Monkey Expected from Sequence
Sheep Expected from Sequence
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Antiserum Preparation
Antisera to Human EGR1 were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG prepared from whole serum by affinity chromatography.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
<0.1% Sodium Azide (NaN3)
Immunogen
A synthetic peptide sequence corresponding to amino acid 94 - 108 of human EGR1.
Approx. Protein Concentrations
IgG concentration 0.5 mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA
Immunohistology - Paraffin 1 10ug/ml
Western Blotting
  1. 1This product requires antigen retrieval using heat treatment prior to staining of paraffin sections.Sodium citrate buffer pH 6.0 is recommended for this purpose.
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Histology Positive Control Tissue
Lung small cell carcinoma

Description Product Code Applications Pack Size List Price Your Price Quantity
Antigen Retrieval Buffer, pH8.0 BUF025A P 500 ml
List Price Your Price
Description Antigen Retrieval Buffer, pH8.0
TidyBlot Western Blot Detection Reagent:HRP STAR209P WB* 0.5 ml
List Price Your Price
Description TidyBlot Western Blot Detection Reagent:HRP

References for EGR1 antibody

  1. Abu El-Asrar, A.M. et al (2011) Expression of high-mobility groups box-1/receptor for advanced glycation end products/osteopontin/early growth response-1 pathway in proliferative vitreoretinal epiretinal membranes
    Mol Vis. 2011 Feb 17;17:508-18.

Immunohistology - Paraffin

RRID
AB_2262092
UniProt
P18146
Entrez Gene
EGR1
GO Terms
GO:0005515 protein binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0008270 zinc ion binding
GO:0060337 type I interferon-mediated signaling pathway
GO:0071504 cellular response to heparin
GO:0071506 cellular response to mycophenolic acid
GO:0072303 positive regulation of glomerular metanephric mesangial cell proliferation
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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