EGF R (pSer1046) antibody

Rabbit anti EGF R (pSer1046)

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
EGF R (pSer1046)

Product Code Applications Pack Size List Price Your Price Qty
AHP2586
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
WB 50 µl loader
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Rabbit anti EGF R (pSer1046) antibody recognizes the epidermal growth factor receptor (EGF R), also known as proto-oncogene c-ErbB-1 or receptor tyrosine-protein kinase erbB-1, when phosphorylated at serine 1046. EGF R is a transmembrane glycoprotein and a member of the ErbB receptor tyrosine kinase family. EGFR is a cell surface receptor for members of the epidermal growth factor family.

EGF R plays a role in numerous cellular processes such as cell proliferation and apoptosis through the activation of downstream signaling pathways (Scaltriti and Baselga 2006).

EGF R is autophosphorylated at serine 1046 and serine 1047 upon ligand binding and receptor dimerization. Phosphorylation of serine 1046 and serine 1047 plays an important role in EGF R desensitization (Sun et al. 2010).

Target Species
Human
Product Form
Purified IgG - liquid
Antiserum Preparation
Antiserum to EGF R (pSer1046) was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.02% Sodium Azide
50% Glycerol
Immunogen
Phospho specific-peptide corresponding to residues surrounding serine1046 of human EGF R
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/500 1/1000
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

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Further Reading

  1. Scaltriti, M. & Baselga, J. (2006) The epidermal growth factor receptor pathway: a model for targeted therapy.
    Clin Cancer Res. 12 (18): 5268-72.
  2. Sun, Q. et al. (2010) Additional serine/threonine phosphorylation reduces binding affinity but preserves interface topography of substrate proteins to the c-Cbl TKB domain.
    PLoS One. 5 (9): e12819.

UniProt
P00533
Entrez Gene
EGFR
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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