EGF R (pSer1046) antibody
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WB ResetRabbit anti EGF R (pSer1046)
- Product Type
- Polyclonal Antibody
- Isotype
- Polyclonal IgG
- Specificity
- EGF R (pSer1046)
Antibody Quality and Performance Guarantee
| Rabbit anti EGF R (pSer1046) antibody recognizes the epidermal growth factor receptor (EGF R), also known as proto-oncogene c-ErbB-1 or receptor tyrosine-protein kinase erbB-1, when phosphorylated at serine 1046. EGF R is a transmembrane glycoprotein and a member of the ErbB receptor tyrosine kinase family. EGFR is a cell surface receptor for members of the epidermal growth factor family. EGF R plays a role in numerous cellular processes such as cell proliferation and apoptosis through the activation of downstream signaling pathways (Scaltriti and Baselga 2006). EGF R is autophosphorylated at serine 1046 and serine 1047 upon ligand binding and receptor dimerization. Phosphorylation of serine 1046 and serine 1047 plays an important role in EGF R desensitization (Sun et al. 2010). |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antiserum to EGF R (pSer1046) was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.05% Proclin™300
50% Glycerol - Immunogen
- Phospho specific-peptide corresponding to residues surrounding serine1046 of human EGF R
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
- Acknowledgements
- ProClin™ is a trademark of The Dow Chemical Company (“Dow”) or an affiliated company of Dow.
Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting |  |
1/500 | 1/1000 |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
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Further Reading
-
Scaltriti, M. & Baselga, J. (2006) The epidermal growth factor receptor pathway: a model for targeted therapy.
Clin Cancer Res. 12 (18): 5268-72. -
Sun, Q. et al. (2010) Additional serine/threonine phosphorylation reduces binding affinity but preserves interface topography of substrate proteins to the c-Cbl TKB domain.
PLoS One. 5 (9): e12819.
AHP2586
141548
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