Rabbit anti E3 ubiquitin-protein ligase CBL (pTyr700) antibody
recognizes the Casitas B-lineage lymphoma (CBL) E3 ubiquitin ligase, also known as c-CBL proto-oncogene and ring finger protein 55, when phosphorylated at tyrosine 700. The CBL protein is a RING finger E3-ubiquitin ligase that plays a key role in signal transduction through mediating monoubiquitination and endocytosis of receptor tyrosine kinases (Haglund et al. 2002
, Dikic and Giordano 2003
E3 ubiqutin-protein ligase CBL is phosphorylated at tyrosine 700 by Fyn, Yes and Syk (Feshchenko et al. 1998
- Target Species
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antiserum to E3 ubiqutin-protein ligase CBL (pTyr700) was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.02% Sodium Azide
- Phospho specific-peptide corresponding to residues surrounding tyrosine 700 of human E3 ubiqutin-protein ligase CBL
- Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
calcium ion binding
sequence-specific DNA binding transcription factor activity
ubiquitin-protein ligase activity
signal transducer activity
epidermal growth factor receptor signaling pathway
zinc ion binding
SH3 domain binding
negative regulation of epidermal growth factor receptor signaling pathway
positive regulation of receptor-mediated endocytosis
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of E3 UBIQUITIN-PROTEIN Ligase CBL (pTyr700) antibody
|Immunohistology - Paraffin
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
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Secondary Antibodies Available
Useful Reagents Available