E3 UBIQUITIN-PROTEIN Ligase CBL antibody
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WB ResetRabbit anti E3 UBIQUITIN-PROTEIN Ligase CBL
- Product Type
- Polyclonal Antibody
- Isotype
- Polyclonal IgG
- Specificity
- E3 UBIQUITIN-PROTEIN Ligase CBL
Antibody Quality and Performance Guarantee
| Rabbit anti E3 ubiquitin-protein ligase CBL antibody recognizes the Casitas B-lineage lymphoma (CBL) E3 ubiquitin ligase, also known as c-CBL proto-oncogene and ring finger protein 55. As the name implies, the viral form of CBL, v-CBL, has been shown to induce lymphoma and leukemia in mice (de Jong et al. 1995). The CBL protein is a RING finger E3-ubiquitin ligase that plays a key role in signal transduction processes through mediating monoubiquitination and thereby endocytosis of receptor tyrosine kinases (Haglund et al. 2002, Dikic and Giordano 2003). In addition to this role, CBL has also been reported to act as an adaptor protein as well as a mediator of cell signaling processes by changing the cellular localization of substrates (Liyasova et al. 2015). |
- Target Species
- Human
- Species Cross-Reactivity
-
Target Species Cross Reactivity Mouse Rat - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography
- Antiserum Preparation
- Antiserum to E3 ubiquitin-protein ligase CBL was raised by repeated immunisation of rabbits with highly purified antigen
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.1% Sodium Azide (NaN3)
0.2% Gelatin - Immunogen
- Peptide mapping to the carboxy terminal domain of human E3 ubiquitin-protein ligase CBL
- Approx. Protein Concentrations
- IgG concentration 0.2 mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
Store at +4oC. DO NOT FREEZE.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting |  |
1/200 |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Western Blotting
- Rabbit anti E3 ubiquitin-protein ligase CBL recogninizes a band of approximately117 kDa when run under reducing conditions
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- UniProt
- P22681
- Entrez Gene
- CBL
- GO Terms
- GO:0005509 calcium ion binding
- GO:0003700 sequence-specific DNA binding transcription factor activity
- GO:0005829 cytosol
- GO:0004842 ubiquitin-protein ligase activity
- GO:0004871 signal transducer activity
- GO:0005634 nucleus
- GO:0007173 epidermal growth factor receptor signaling pathway
- GO:0008270 zinc ion binding
- GO:0017124 SH3 domain binding
- View More GO Terms
- GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
- GO:0048260 positive regulation of receptor-mediated endocytosis
AHP2416
157189
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