Drebrin 1 antibody

Rabbit anti Drebrin 1

Product Type
PrecisionAb Polyclonal
Isotype
Polyclonal IgG
Format
Purified
Specificity
Drebrin 1

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VPA00848
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Rabbit anti Human drebrin 1 antibody recognizes drebrin 1, also known as developmentally-regulated brain protein-drebrin, drebrin E, DBN1 and drebrin E2.

The protein encoded by DBN1 is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for DBN1 (provided by RefSeq, Jul 2008).

Rabbit anti Human drebrin 1 antibody detects bands of 110-132 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Anti drebrin 1 antibody recognizes a band of approximately 110-132 kDa in SH-SY5Y cell lysates
Product Form
Purified IgG - liquid
Preparation
Rabbit polyclonal antibody purified by affinity chromatography on immunogen
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide
Immunogen
KLH conjugated synthetic peptide corresponding to amino acids 1-28 of human drebrin 1
Regulatory
For research purposes only
Guarantee
12 months from date of despatch
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories

Store undiluted at -20°C, avoiding repeated freeze thaw cycles

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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UniProt
Q16643
Entrez Gene
DBN1
GO Terms
GO:0003779 actin binding
GO:0005522 profilin binding
GO:0005737 cytoplasm
GO:0007015 actin filament organization
GO:0030425 dendrite
GO:0042641 actomyosin
GO:0048168 regulation of neuronal synaptic plasticity
GO:0050773 regulation of dendrite development
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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