Drebrin 1 antibody
Rabbit anti Human drebrin 1 antibody recognizes drebrin 1, also known as developmentally-regulated brain protein-drebrin, drebrin E, DBN1 and drebrin E2.
The protein encoded by DBN1 is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for DBN1 (provided by RefSeq, Jul 2008).
Rabbit anti Human drebrin 1 antibody detects bands of 110-132 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
The protein encoded by DBN1 is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for DBN1 (provided by RefSeq, Jul 2008).
Rabbit anti Human drebrin 1 antibody detects bands of 110-132 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
Product Details
- Target Species
- Human
- Western Blotting
- Anti drebrin 1 antibody recognizes a band of approximately 110-132 kDa in SH-SY5Y cell lysates
- Product Form
- Purified IgG - liquid
- Preparation
- Rabbit polyclonal antibody purified by affinity chromatography on immunogen
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
- Immunogen
- KLH conjugated synthetic peptide corresponding to amino acids 1-28 of human drebrin 1
Storage Information
- Storage
- Store undiluted at -20°C, avoiding repeated freeze thaw cycles
- Guarantee
- 12 months from date of despatch
More Information
- UniProt
- Q16643
- Entrez Gene
- DBN1
- GO Terms
- GO:0003779 actin binding
- GO:0005522 profilin binding
- GO:0005737 cytoplasm
- GO:0007015 actin filament organization
- GO:0030425 dendrite
- GO:0042641 actomyosin
- GO:0048168 regulation of neuronal synaptic plasticity
- GO:0050773 regulation of dendrite development
- Acknowledgements
- PrecisionAb is a trademark of Bio-Rad Laboratories
- Regulatory
- For research purposes only
Applications of Drebrin 1 antibody
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting | 1/1000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
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Secondary Antibodies Available
| Description | Product Code | Applications | Pack Size | List Price | Quantity |
|---|---|---|---|---|---|
| Goat anti Rabbit IgG (H/L):HRP | STAR208P | WB | 2 ml |
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