Drebrin 1 antibody
Rabbit anti Human drebrin 1 antibody recognizes drebrin 1, also known as developmentally-regulated brain protein, or DBN1.
The protein encoded by DBN1 is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for DBN1 (provided by RefSeq, Jul 2008).
Rabbit anti Human drebrin 1 antibody detects bands of 110-132 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
The protein encoded by DBN1 is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for DBN1 (provided by RefSeq, Jul 2008).
Rabbit anti Human drebrin 1 antibody detects bands of 110-132 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
Product Details
- Target Species
- Human
- Western Blotting
- Anti drebrin 1 antibody recognizes a band of approximately 110-132 kDa in SH-SY5Y cell lysates
- Species Cross-Reactivity
-
Target Species Cross Reactivity Mouse - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Preparation
- Rabbit polyclonal antibody purified by affinity chromatography on immunogen
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
<50% Glycerol - Immunogen
- Recombinant protein of human drebrin 1
- Instructions For Use
- Please refer to the PrecisionAb western blotting protocol. For additional information on secondary antibody dilution and exposure time see product web page.
Storage Information
- Storage
- Store undiluted at -20°C, avoiding repeated freeze thaw cycles
- Shelf Life
- As supplied, 12 months from date of despatch
More Information
- UniProt
- Q16643 Related reagents
- Entrez Gene
- DBN1 Related reagents
- GO Terms
- GO:0003779 actin binding
- GO:0005522 profilin binding
- GO:0005737 cytoplasm
- GO:0007015 actin filament organization
- GO:0030425 dendrite
- GO:0042641 actomyosin
- GO:0048168 regulation of neuronal synaptic plasticity
- GO:0050773 regulation of dendrite development
- Acknowledgements
- PrecisionAb™ is a trademark of Bio-Rad Laboratories
- Regulatory
- For research purposes only
Applications of Drebrin 1 antibody
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting | 1/1000 |
PrecisionAb antibodies have been extensively validated for the western blot application. The antibody has been validated at the suggested dilution. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependant on sample type.
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Secondary Antibodies Available
| Description | Product Code | Pack Size | Applications | List Price | Quantity |
|---|---|---|---|---|---|
| Goat anti Rabbit IgG (H/L):HRP | STAR208P | 2 ml | WB |
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