DR3 antibody

Rabbit anti Human DR3 (Ed)

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
DR3
Region
(ED)

Product Code Applications Pack Size List Price Your Price Qty
AHP437
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
C WB * 0.1 mg loader
List Price Your Price
loader
Search for Batch Specific Datasheets

Rabbit anti Human DR3 recognizes death receptor 3. DR3 is a cell surface receptor containing a death domain, with functional similarities to TNFR1 and Fas/CD95 (Chinnaiyan et al. 1996). The receptor for DR3 is also known as Apo-3L (Marsters et al. 1998), Wsl-1, Apo-3, TRAMP and LARD. DR3 is an inducer of apoptosis and NF-KB activation (Sheikh and Huang 2003).

Target Species
Human
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Antiserum Preparation
Antisera to DR3 were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG prepared by ion exchange chromatography.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.02%Sodium Azide
Immunogen
Peptide from extracellular domain of human DR3.
Approx. Protein Concentrations
IgG concentration 1mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunohistology - Frozen
Western Blotting 1 1.0 5.0ug/ml
  1. 1This product detects a band of approximately 59kDa under both reducing and denaturing conditions.
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.

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Further Reading

  1. Chinnaiyan, A.M. et al. (1996) Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95.
    Science. 274 (5289): 990-2.
  2. Marsters, S.A. et al. (1998) Identification of a ligand for the death-domain-containing receptor Apo3.
    Curr Biol. 8 (9): 525-8.

Synonyms
Tumor Necrosis Factor Receptor Superfamily Member 25
RRID
AB_322733
UniProt
Q93038
Entrez Gene
TNFRSF25
View more products with DR3 specificity

Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

View all Anti-Human Products