DR3 antibody

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Rabbit anti Human DR3 (Ed)

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Product Code Applications Pack Size List Price Quantity
AHP437
Datasheet
C WB*
MSDS
0.1 mg loader

Rabbit anti Human DR3 recognizes death receptor 3. DR3 is a cell surface receptor with a death domain, with functional similarities to TNFR1 and Fas/CD95 (Chinnaiyan, A. et al. 1996). The receptor for DR3 has very recently been identified and has been termed Apo-3L (Marsters, S. et al. 1998). DR3 itself has also been called Wsl-1, Apo-3, TRAMP and LARD, a functionally induces apoptosis and NF-KB activation.

Product Details

Target Species
Human
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Antiserum Preparation
Antisera to DR3 were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG prepared by ion exchange chromatography.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.02%Sodium Azide
Immunogen
Peptide from extracellular domain of human DR3.
Approx. Protein Concentrations
IgG concentration 1mg/ml

Storage Information

Storage
Store at +4oC or at -20oC if preferred.

This product should be stored undiluted.

Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Guarantee
12 months from date of despatch

More Information

UniProt
Q93038
Entrez Gene
TNFRSF25
Regulatory
For research purposes only

Applications of DR3 antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunohistology - Frozen
Western Blotting 1 1.0 5.0ug/ml
  1. 1This product detects a band of approximately 59kDa under both reducing and denaturing conditions.
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.

Secondary Antibodies Available

Description Product Code Applications Pack Size List Price Quantity
Goat anti Rabbit IgG (Fc):Biotin STAR121B E WB 1 mg loader
Goat anti Rabbit IgG (Fc):FITC STAR121F F 1 mg loader
Goat anti Rabbit IgG (Fc):HRP STAR121P E WB 1 mg loader
Goat anti Rabbit IgG (H/L):HRP STAR124P C E WB 1 mg loader
Sheep anti Rabbit IgG:FITC STAR34B C F 1 mg loader
Sheep anti Rabbit IgG:RPE STAR35A F 1 ml loader
Sheep anti Rabbit IgG:DyLight®488 STAR36D488GA F IF WB 0.1 mg
Sheep anti Rabbit IgG:DyLight®680 STAR36D680GA F IF WB 0.1 mg
Sheep anti Rabbit IgG:Dylight®800 STAR36D800GA F IF WB 0.1 mg

Product Specific References

Further Reading

  1. Chinnaiyan, A.M. et al. (1996) Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95.
    Science. 274 (5289): 990-2.
  2. Marsters, S.A. et al. (1998) Identification of a ligand for the death-domain-containing receptor Apo3.
    Curr Biol. 8 (9): 525-8.