DEDAF antibody


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WB P ResetRabbit anti Human DEDAF
- Product Type
- Polyclonal Antibody
- Isotype
- Polyclonal IgG
- Specificity
- DEDAF
Rabbit anti Human DEDAF antibody recognizes human death effector domain associated factor (DEDAF), also known as RING1 and YY1-binding protein, apoptin-associating protein 1 or death effector domain-associated factor or YY1 and E4TF1-associated factor 1. DEDAF is a 228 amino acid, ~32 kDa protein that associates with DED-containing proteins but does not itself contain a DED. DEDAF interacts with the death effector domains of FADD, DEDD and the proforms of caspase-8 and caspase-10. It augments the formation of complexes between CD95, FADD and caspase-8 at the cell membrane and enhances apoptosis. The protein, identified as RING1 and YY1 binding protein (RYBP) is implicated in the regulation of transcription (Sawa et al. 2002). |
- Target Species
- Human
- Species Cross-Reactivity
-
Target Species Cross Reactivity Mouse Rat - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antiserum to human DEDAF was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.02% Sodium Azide (NaN3)
- Immunogen
- A peptide corresponding to amino acids 215-228 of human DEDAF.
- Approx. Protein Concentrations
- IgG concentration 1 mg/ml.
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
Immunohistology - Paraffin 1 | ![]() |
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Western Blotting | ![]() |
0.5 | 1.0ug/ml |
- 1 This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose.
- Western Blotting
- AHP1605 detects a band of approximately 32kDa in human A549 cell lysates.
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- Synonyms
- APAP1
- RRID
- AB_2285467
- UniProt
- Q8N488
- Entrez Gene
- RYBP
- GO Terms
- GO:0000122 negative regulation of transcription from RNA polymerase II promoter
- GO:0003677 DNA binding
- GO:0003714 transcription corepressor activity
- GO:0006915 apoptosis
- GO:0005634 nucleus
- GO:0005737 cytoplasm
- GO:0007275 multicellular organismal development
- GO:0008270 zinc ion binding
AHP1605

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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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