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Decorin antibody

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Sheep anti Human Decorin

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
Decorin

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Product Code Applications Pack Size List Price Your Price Qty
7870-6190
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
E WB 1 ml
List Price Your Price

Sheep anti human decorin antibody recognizes the C-terminal region of human bone proteoglycan II, also known as decorin, PG-S2 or PG40. Mutations in the decorin gene are associated with congenital stromal dystrophy of the cornea (CSCD), a rare autosomal dominant eye disease characterized by bilateral corneal clouding (Bredrup et al., 2005). Decorin is involved in autophagy of endothelial cells (Buraschi et al., 2013).

Target Species
Human
Species Cross-Reactivity
Target SpeciesCross Reactivity
Bovine
Chicken
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography on Protein G
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
Immunogen
Synthetic peptide, CVYVRSAIQLGNYK, corresponding to the C-terminal sequence of human decorin conjugated to Keyhole Limpet Haemocyanin.
Approx. Protein Concentrations
IgG concentration 5.0 mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA
Western Blotting
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using the appropriate negative/positive controls.

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Further Reading

  1. Bredrup, C. et al. (2005) Congenital stromal dystrophy of the cornea caused by a mutation in the decorin gene.
    Invest Ophthalmol Vis Sci. 46: 420-6.
  2. Buraschi, S. et al. (2013) Decorin causes autophagy in endothelial cells via Peg3.
    Proc Natl Acad Sci U S A. 110: E2582-91

Synonyms
Bone Proteoglycan II
RRID
AB_2169109
UniProt
P07585
Entrez Gene
DCN
GO Terms
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
GO:0009887 organ morphogenesis

7870-6190

1711

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