Decorin antibody
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Sheep anti human decorin antibody recognizes the C-terminal region of human bone proteoglycan II, also known as decorin, PG-S2 or PG40. Mutations in the decorin gene are associated with congenital stromal dystrophy of the cornea (CSCD), a rare autosomal dominant eye disease characterized by bilateral corneal clouding (Bredrup et al., 2005). Decorin is involved in autophagy of endothelial cells (Buraschi et al., 2013).
Product Details
- Target Species
- Human
- Species Cross-Reactivity
-
Target Species Cross Reactivity Bovine Chicken - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein G
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Immunogen
- Synthetic peptide, CVYVRSAIQLGNYK, corresponding to the C-terminal sequence of human decorin conjugated to Keyhole Limpet Haemocyanin.
- Approx. Protein Concentrations
- IgG concentration 5.0 mg/ml
Storage Information
- Storage
- This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. - Guarantee
- 12 months from date of despatch
More Information
- UniProt
- P07585
- Entrez Gene
- DCN
- GO Terms
- GO:0005578 proteinaceous extracellular matrix
- GO:0005615 extracellular space
- GO:0009887 organ morphogenesis
- Regulatory
- For research purposes only
Applications of Decorin antibody
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA | |||
| Western Blotting |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using the appropriate negative/positive controls.
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Secondary Antibodies Available
| Description | Product Code | Applications | Pack Size | List Price | Quantity |
|---|---|---|---|---|---|
| Rabbit anti Sheep IgG (H/L):Biotin | 5184-2304 | C E F WB | 1.5 ml |
|
|
| Donkey anti Sheep/Goat IgG:DyLight®488 | STAR88D488GA | F IF | 0.1 mg |
|
|
| Donkey anti Sheep/Goat IgG:HRP | STAR88P | C E P WB | 1 ml |
|
Product Specific References
Further Reading
-
Bredrup, C. et al. (2005) Congenital stromal dystrophy of the cornea caused by a mutation in the decorin gene.
Invest Ophthalmol Vis Sci. 46: 420-6. -
Buraschi, S. et al. (2013) Decorin causes autophagy in endothelial cells via Peg3.
Proc Natl Acad Sci U S A. 110: E2582-91
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