Decorin antibody

100% Secure

Sheep anti Human Decorin

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Product CodeApplicationsDatasheetMSDSPack SizeList PriceQuantity
7870-6190 E WB 1 ml
Sheep anti human decorin antibody recognizes the C-terminal region of human bone proteoglycan II, also known as decorin, PG-S2 or PG40. Mutations in the decorin gene are associated with congenital stromal dystrophy of the cornea (CSCD), a rare autosomal dominant eye disease characterized by bilateral corneal clouding (Bredrup et al., 2005). Decorin is involved in autophagy of endothelial cells (Buraschi et al., 2013).

Product Details

Target Species
Human
Species Cross-Reactivity
Target SpeciesCross Reactivity
Bovine
Chicken
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography on Protein G
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
Immunogen
Synthetic peptide, CVYVRSAIQLGNYK, corresponding to the C-terminal sequence of human decorin conjugated to Keyhole Limpet Haemocyanin.
Approx. Protein Concentrations
IgG concentration 5.0 mg/ml

Storage Information

Storage
Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted.
Avoid repeated freezing and thawing as this may denature the antibody.
Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life
18 months from date of despatch.

More Information

UniProt
P07585 Related reagents
Entrez Gene
DCN Related reagents
GO Terms
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
GO:0009887 organ morphogenesis
Regulatory
For research purposes only

Applications of Decorin antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA
Western Blotting
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using the appropriate negative/positive controls.

Secondary Antibodies Available

Description Product Code Pack Size Applications List Price Quantity
Rabbit anti Sheep IgG (H/L):Biotin 5184-2304 1.5 ml C E F WB
Donkey anti Sheep/Goat IgG:DyLight®488 STAR88D488GA 0.1 mg F IF
Donkey anti Sheep/Goat IgG:DyLight®549 STAR88D549GA 0.1 mg F IF
Donkey anti Sheep/Goat IgG:DyLight®649 STAR88D649GA 0.1 mg F IF
Donkey anti Sheep/Goat IgG:FITC STAR88F 1 mg C
Donkey anti Sheep/Goat IgG:HRP STAR88P 1 ml C E P WB

Product Specific References

Further Reading

  1. Bredrup, C. et al. (2005) Congenital stromal dystrophy of the cornea caused by a mutation in the decorin gene.
    Invest Ophthalmol Vis Sci. 46: 420-6.
  2. Buraschi, S. et al. (2013) Decorin causes autophagy in endothelial cells via Peg3.
    Proc Natl Acad Sci U S A. 110: E2582-91