Goat anti DDX41 antibody
recognizes probable ATP-dependent RNA helicase DDX41, also known as DEAD box protein 41 and ABS.
DDX41 is a helicase and a member of the DEAD-box family of proteins. It functions through the STING-TBK1-IRF3 pathway during innate immunity (Jiang et al. 2017
) and is an important sensor of DNA viruses including HSV-1 and adenovirus, directly binding to DNA and STING via its DEADc domain (Zhang et al. 2011
). DDX41 has been associated with hematological malignancies, with mutations in DDX41 identified in patients with myeloid neoplasms (Peters et al. 2017
- Target Species
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antisera to human DDX41 were raised by repeated immunizations of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography.
- Buffer Solution
- TRIS buffered saline
- Preservative Stabilisers
- 0.02% Sodium Azide
0.5% Bovine Serum Albumin
- Peptide with sequence C-QEERTKAIEAFRE, from the internal region of the protein sequence according to NP_057306.2
- Approx. Protein Concentrations
- IgG concentration 0.5 mg/ml
- Store at -20°C only.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
multicellular organismal development
ATP-dependent helicase activity
zinc ion binding
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of DDX41 antibody
|Immunohistology - Paraffin
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Western Blotting
- Goat anti Human DDX41 antibody detects a band of approximately 85 kDa in cell lysates
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Secondary Antibodies Available
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