DDX41 antibody

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Anti DDX41 Antibody gallery image 1 — Western blot analysis of human bone marrow lysate (35µg protein in RIPA buffer) probed with DDX41 antibody (0.5 µg/ml,**AHP3024**) and detected by chemiluminescence.

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Goat anti DDX41

Product Type: Polyclonal Antibody
Isotype: Polyclonal IgG
Specificity: DDX41

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AHP3024 Datasheet Datasheet SDS SDS	P WB	0.1 mg		Log in	Get Quote
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Goat anti DDX41 antibody recognizes probable ATP-dependent RNA helicase DDX41, also known as DEAD box protein 41 and ABS.

DDX41 is a helicase and a member of the DEAD-box family of proteins. It functions through the STING-TBK1-IRF3 pathway during innate immunity (Jiang et al. 2017) and is an important sensor of DNA viruses including HSV-1 and adenovirus, directly binding to DNA and STING via its DEADc domain (Zhang et al. 2011). DDX41 has been associated with hematological malignancies, with mutations in DDX41 identified in patients with myeloid neoplasms (Peters et al. 2017).

Target Species: Human
Product Form: Purified IgG - liquid
Antiserum Preparation: Antisera to human DDX41 were raised by repeated immunizations of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography.
Buffer Solution: TRIS buffered saline
Preservative Stabilisers: 0.02% Sodium Azide
0.5% Bovine Serum Albumin
Immunogen: Peptide with sequence C-QEERTKAIEAFRE, from the internal region of the protein sequence according to NP_057306.2
Approx. Protein Concentrations: IgG concentration 0.5 mg/ml
Regulatory: For research purposes only
Guarantee: 12 months from date of despatch

Store at -20°C only.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
Immunohistology - Paraffin		5 ug/ml
Western Blotting		0.5 ug/ml	2 ug/ml

Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

Western Blotting: Goat anti Human DDX41 antibody detects a band of approximately 85 kDa in cell lysates

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UniProt: Q9UJV9
Entrez Gene: DDX41
GO Terms: GO:0005515 protein binding; GO:0003723 RNA binding; GO:0006915 apoptosis; GO:0005524 ATP binding; GO:0005681 spliceosomal complex; GO:0006397 mRNA processing; GO:0007275 multicellular organismal development; GO:0008026 ATP-dependent helicase activity; GO:0008380 RNA splicing; View More GO Terms; GO:0008270 zinc ion binding