DDX41 antibody

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Goat anti DDX41

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Product Code Applications Pack Size List Price Quantity
AHP3024
Datasheet
P WB
SDS
0.1 mg

Goat anti DDX41 antibody recognizes probable ATP-dependent RNA helicase DDX41, also known as DEAD box protein 41 and ABS.

DDX41 is a helicase and a member of the DEAD-box family of proteins. It functions through the STING-TBK1-IRF3 pathway during innate immunity (Jiang et al. 2017) and is an important sensor of DNA viruses including HSV-1 and adenovirus, directly binding to DNA and STING via its DEADc domain (Zhang et al. 2011). DDX41 has been associated with hematological malignancies, with mutations in DDX41 identified in patients with myeloid neoplasms (Peters et al. 2017).

Product Details

Target Species
Human
Product Form
Purified IgG - liquid
Antiserum Preparation
Antisera to human DDX41 were raised by repeated immunizations of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography.
Buffer Solution
TRIS buffered saline
Preservative Stabilisers
0.02% Sodium Azide
0.5% Bovine Serum Albumin
Immunogen
Peptide with sequence C-QEERTKAIEAFRE, from the internal region of the protein sequence according to NP_057306.2
Approx. Protein Concentrations
IgG concentration 0.5 mg/ml

Storage Information

Storage
Store at +4oC or at -20oC if preferred.

This product should be stored undiluted.

Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Guarantee
12 months from date of despatch

More Information

UniProt
Q9UJV9
Entrez Gene
DDX41
GO Terms
GO:0005515 protein binding
GO:0003723 RNA binding
GO:0006915 apoptosis
GO:0005524 ATP binding
GO:0005681 spliceosomal complex
GO:0006397 mRNA processing
GO:0007275 multicellular organismal development
GO:0008026 ATP-dependent helicase activity
GO:0008380 RNA splicing
GO:0008270 zinc ion binding
Regulatory
For research purposes only

Applications of DDX41 antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunohistology - Paraffin 5 ug/ml
Western Blotting 0.5 ug/ml 2 ug/ml
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Western Blotting
Goat anti Human DDX41 antibody detects a band of approximately 85 kDa in cell lysates

Secondary Antibodies Available

Description Product Code Applications Pack Size List Price Quantity
Rabbit anti Goat IgG (Fc):FITC STAR122F F 1 mg loader
Rabbit anti Goat IgG (Fc):HRP STAR122P C E WB 1 mg loader

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