DAXX antibody
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P ResetRabbit anti Human DAXX
- Product Type
- Polyclonal Antibody
- Isotype
- Polyclonal IgG
- Specificity
- DAXX
Antibody Quality and Performance Guarantee
| Rabbit anti Human DAXX antibody recognises human Death Domain-Associated Protein 6, a novel Fas binding protein that has been designated DAXX. DAXX binds specifically to the death domain of Fas and enhances Fas induced apoptosis and activates the Jun N-terminal kinase (JNK) pathway. DAXX is predominantly a nuclear protein, where it acts as a repressor of EtsI and Pax3 transactivation. When in association with ASK1 kinase DAXX translocates from the nucleus to the cytoplasm. |
- Target Species
- Human
- Species Cross-Reactivity
-
Target Species Cross Reactivity Rat Mouse - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antiserum to human DAXX was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- <0.1% Sodium Azide (NaN3)
- Immunogen
- Synthetic peptide corresponding to amino acids 261-274 of human DAXX protein.
- Approx. Protein Concentrations
- IgG concentration 1.0mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA |  |
1/7000 | 1/45000 |
| Immunohistology - Paraffin 1 | |
2.5ug/ml | |
| Western Blotting | |
1/200 | 1/1000 |
- 1This product requires antigen retrieval using heat treatment prior to staining of paraffin sections.Sodium citrate buffer pH 6.0 is recommended for this purpose.
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Histology Positive Control Tissue
- Human kidney
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- RRID
- AB_2088899
- UniProt
- Q9UER7
- Entrez Gene
- DAXX
- GO Terms
- GO:0000775 chromosome, centromeric region
- GO:0002039 p53 binding
- GO:0006915 apoptosis
- GO:0005057 receptor signaling protein activity
- GO:0005730 nucleolus
- GO:0006350 transcription
- GO:0007257 activation of JUN kinase activity
- GO:0008134 transcription factor binding
- GO:0008625 induction of apoptosis via death domain receptors
- View More GO Terms
- GO:0016481 negative regulation of transcription
- GO:0016605 PML body
- GO:0031072 heat shock protein binding
- GO:0030521 androgen receptor signaling pathway
- GO:0031396 regulation of protein ubiquitination
- GO:0031625 ubiquitin protein ligase binding
- GO:0042803 protein homodimerization activity
- GO:0044419 interspecies interaction between organisms
- GO:0045892 negative regulation of transcription, DNA-dependent
- GO:0047485 protein N-terminus binding
- GO:0050681 androgen receptor binding
View more products with DAXX specificity
Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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