Darpp-32 antibody

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Rabbit anti Darpp-32

Product Type
PrecisionAb™ Polyclonal
Isotype
Polyclonal IgG
Format
Purified
Product CodeApplicationsDatasheetMSDSPack SizeList PriceQuantity
VPA00687 WB 100 µl
Rabbit anti Human DARPP-32 antibody recognizes the protein phosphatase 1 regulatory subunit 1B also known as dopamine and cAMP-regulated neuronal phosphoprotein 32.

The PPP1R1B gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, PPP1R1B may serve as a therapeutic target for neurologic and psychiatric disorders. Multiple transcript variants encoding different isoforms have been found for PPP1R1B (provided by RefSeq, Oct 2011).

Rabbit anti Human DARPP-32 antibody detects a band of 32 kDa. The antibody has been extensively validated for western blotting using mouse brain tissue lysate.

Product Details

Target Species
Human
Western Blotting
Rabbit anti DARPP-32 detects a band of approximately 32 kDa in mouse brain tissue
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Preparation
Rabbit polyclonal antibody purified by affinity chromatography on Protein A
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide
Immunogen
KLH conjugated synthetic peptide encompassing part of human DARPP-32 (amino acids 106 - 139)
Instructions For Use
Please refer to the PrecisionAb western blotting protocol. For additional information on secondary antibody dilution and exposure time see product web page.

Storage Information

Storage
Store undiluted at -20oC, avoiding repeated freeze thaw cycles.
Shelf Life
As supplied, 12 months from date of despatch.

More Information

UniProt
Q9UD71 Related reagents
Entrez Gene
PPP1R1B Related reagents
GO Terms
GO:0005829 cytosol
GO:0004860 protein kinase inhibitor activity
GO:0004864 protein phosphatase inhibitor activity
GO:0007165 signal transduction
Acknowledgements
PrecisionAbâ„¢ is a trademark of Bio-Rad Laboratories.
Regulatory
For research purposes only

Applications of Darpp-32 antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000

PrecisionAb antibodies have been extensively validated for the western blot application. The antibody has been validated at the suggested dilution. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependant on sample type.

Secondary Antibodies Available

Description Product Code Pack Size Applications List Price Quantity
Goat anti Rabbit IgG (H/L):HRP STAR208P 2 ml WB

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