Rabbit anti Human cytochrome P450 1A2 antibody recognizes human cytochrome p450 1A2 (CYP1A2). P450 enzymes are divided into two groups: steroidogenic and xenobiotic. The latter group is comprised of three families 1, 2 and 3. The xenobiotic p450's are involved in most oxidative drug metabolism. Drug metabolism is mediated by family members:CYP3A, CYP2D6, CYP1A2, CYP2C9/10, CYP2C19 and CYP2E1. Rabbit anti Human cytochrome P450 1A2 antibody (AHP610Z) is a neutralizing antibody which is a specific and potent inhibitor of CYP1A2 activity.
- Target Species
- Product Form
- Serum - liquid
- Antiserum Preparation
- Antisera to human CYP1A2 were raised by repeated immunisation of rabbits with highly purified antigen.
- Preservative Stabilisers
- None Present
- Purified human CYP1A2 expressed in E.coli.
- Store at -20oC. Ship at +4oC
This product should be stored undiluted.
Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- 18 months from date of despatch.
- Entrez Gene
- GO Terms
electron carrier activity
endoplasmic reticulum membrane
steroid catabolic process
xenobiotic metabolic process
toxin biosynthetic process
alkaloid metabolic process
monoterpenoid metabolic process
monocarboxylic acid metabolic process
caffeine oxidase activity
exogenous drug catabolic process
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of Cytochrome P450 1A2 antibody
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
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Secondary Antibodies Available
Useful Reagents Available
Product Specific References
References for Cytochrome P450 1A2 antibody
Werck-Reichhart, D. and Feyereisen, R. (2000) Protein family review Cytochromes P450: a success story.
Genome Biology. 1: 1-9
Ng, P.S. et al. (2003) Production of inhibitory polyclonal antibodies against cytochrome P450s.
Drug Metab Pharmacokinet. 18 (3): 163-72.