Cytochrome P450 1A1 antibody

Rabbit anti Cytochrome P450 1A1

Product Type
PrecisionAb Polyclonal
Isotype
Polyclonal IgG
Format
Purified
Specificity
Cytochrome P450 1A1

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VPA00711
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SDS Safety Datasheet SDS
WB 100 µl loader
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Rabbit anti Human cytochrome P450 1A1 antibody recognizes CYP1A1, also known as AHRR, aryl hydrocarbon hydroxylase, dioxin-inducible cytochrome P450 1A1, flavoprotein-linked monooxygenase or xenobiotic monooxygenase.

The CYP1A1 gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15 (provided by RefSeq, Jul 2008).

Rabbit anti Human cytochrome P450 1A1 antibody detects a band of 58 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Rabbit anti cytochrome P450 1A1 detects a band of approximately 58 kDa in HEK293 cell lysates.
Product Form
Purified IgG - liquid.
Preparation
Rabbit polyclonal antibody purified by affinity chromatography.
Buffer Solution
Phosphate buffered saline.
Preservative Stabilisers
0.09% Sodium Azide
2% Sucrose
Immunogen
Synthetic peptide encompassing part of the middle region of human cytochrome P450 1A1
Regulatory
For research purposes only.
Guarantee
12 months from date of despatch.
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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UniProt
P04798
Entrez Gene
CYP1A1
GO Terms
GO:0009055 electron carrier activity
GO:0005789 endoplasmic reticulum membrane
GO:0005792 microsome
GO:0055114 oxidation-reduction process
GO:0019825 oxygen binding
GO:0017144 drug metabolic process
GO:0020037 heme binding
GO:0042359 vitamin D metabolic process
GO:0070330 aromatase activity
GO:0070576 vitamin D 24-hydroxylase activity

VPA00711

161116

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