Cyclin E antibody

Rabbit anti Cyclin E
- Product Type
- Polyclonal Antibody
- Isotype
- Polyclonal IgG
- Specificity
- Cyclin E
Rabbit anti Human Cyclin E antibody detects cyclin E, a nuclear protein which is the regulatory subunit of cyclin dependent kinase 2 (Cdk2), and controls S phase entry in cells. Cyclin E follows a cyclic pattern of expression during the cell cycle, with highest expression at the G1-S boundary. Although cyclin E has an important physiological role in normal cell division, recent reports suggest this function is redundant, and its key functions occur as cells exit quiescence, and in endoreduplication. Cyclin E is tightly regulated during normal cell cycles, but is often deregulated in carcinomas, lymphoma, and leukaemia. |
- Target Species
- Human
- Species Cross-Reactivity
-
Target Species Cross Reactivity Mouse Rat - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Serum - liquid
- Antiserum Preparation
- Antisera to cyclin E were raised by repeated immunisations of rabbits with highly purified antigen.
- Preservative Stabilisers
- <0.1% Sodium Azide (NaN3)
- Immunogen
- Synthetic peptide corresponding to a region near the C-terminus of human Cyclin E conjugated to KLH.
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
ELISA | ![]() |
1/2000 | |
Immunoprecipitation | ![]() |
1/100 | |
Western Blotting | ![]() |
1/2000 | 1/10 000 |
- Western Blotting
- AHP1245 detects a band of approximately 45kDa in from human, rat and mouse tissue.
Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
---|---|---|---|---|---|---|---|
Goat anti Rabbit IgG (H/L):HRP | STAR124P | C E WB | 1 mg |
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Description | Goat anti Rabbit IgG (H/L):HRP | ||||||
Sheep anti Rabbit IgG:RPE | STAR35A | F | 1 ml |
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Description | Sheep anti Rabbit IgG:RPE | ||||||
Goat anti Rabbit IgG (Fc):Biotin | STAR121B | E WB | 1 mg |
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Description | Goat anti Rabbit IgG (Fc):Biotin | ||||||
Goat anti Rabbit IgG (Fc):FITC | STAR121F | F | 1 mg |
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Description | Goat anti Rabbit IgG (Fc):FITC | ||||||
Sheep anti Rabbit IgG:FITC | STAR34B | C F | 1 mg |
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Description | Sheep anti Rabbit IgG:FITC | ||||||
Goat anti Rabbit IgG (Fc):HRP | STAR121P | E WB | 1 mg |
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Description | Goat anti Rabbit IgG (Fc):HRP |
Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
---|---|---|---|---|---|---|---|
TidyBlot Western Blot Detection Reagent:HRP | STAR209P | WB* | 0.5 ml | Log in | |||
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Description | TidyBlot Western Blot Detection Reagent:HRP |
Further Reading
-
Hwang, H.C. & Clurman, B.E. (2005) Cyclin E in normal and neoplastic cell cycles.
Oncogene. 24 (17): 2776-86. -
Zhang, H. (2007) Life without kinase: cyclin E promotes DNA replication licensing and beyond.
Mol Cell. 25 (2): 175-6.
- Synonyms
- CCNE1
- RRID
- AB_2228590
- UniProt
- P24864
- Entrez Gene
- CCNE1
- GO Terms
- GO:0000083 regulation of transcription involved in G1/S phase of mitotic cell cycle
- GO:0003713 transcription coactivator activity
- GO:0005829 cytosol
- GO:0005654 nucleoplasm
- GO:0030521 androgen receptor signaling pathway
- GO:0045893 positive regulation of transcription, DNA-dependent
- GO:0050681 androgen receptor binding
- GO:0051301 cell division
AHP1245



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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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