CREB1 antibody
Rabbit anti CREB1 antibody recognizes cyclin AMP-responsive element-binding protein 1, also known as CREB-1. It belongs to the family of transcription factors mediating gene expression in neuronal and non-neuronal cells (Lonze et al. 2002). CREB1 is activated in response to growth factor stimulation, electrical stimulation and synaptic activity (Shaywitz and Greenberg 1999). In mice, disruption of CREB1 function results in neurodegeneration (Mantamadiotis et al. 2002). CREB1 is overexpressed in gliomas and promotes gliomagenesis acting as a modulator of oncogenic microRNA-23a (Tan et al. 2012). CREB1, together with SETD2, contribute to cisplatin cytotoxicity regulating the ERK signalling pathway (Kim et al. 2018).
Product Details
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antiserum to CREB1 was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.02% Sodium Azide
50% Glycerol - Immunogen
- Recombinant fusion protein containing a sequence corresponding to amino acids 1-341 of human CREB1
Storage Information
- Storage
- Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. - Guarantee
- 12 months from date of despatch
More Information
- UniProt
- P16220
- Entrez Gene
- CREB1
- GO Terms
- GO:0002755 MyD88-dependent toll-like receptor signaling pathway
- GO:0002756 MyD88-independent toll-like receptor signaling pathway
- GO:0003712 transcription cofactor activity
- GO:0006468 protein phosphorylation
- GO:0007202 activation of phospholipase C activity
- GO:0007268 synaptic transmission
- GO:0007411 axon guidance
- GO:0008063 Toll signaling pathway
- GO:0010033 response to organic substance
- GO:0048015 phosphatidylinositol-mediated signaling
- GO:0034130 toll-like receptor 1 signaling pathway
- GO:0034134 toll-like receptor 2 signaling pathway
- GO:0034138 toll-like receptor 3 signaling pathway
- GO:0034142 toll-like receptor 4 signaling pathway
- GO:0044419 interspecies interaction between organisms
- GO:0045087 innate immune response
- GO:0046983 protein dimerization activity
- GO:0048011 nerve growth factor receptor signaling pathway
- GO:0051403 stress-activated MAPK cascade
- Regulatory
- For research purposes only
Applications of CREB1 antibody
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting | 1/500 | 1/3000 |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Western Blotting
- Rabbit anti CREB1 antibody detects a band of approximately 40 kDa in various cell ant tissue lysates under reducing conditions
Copyright © 2020 Bio-Rad Antibodies (formerly AbD Serotec)
Secondary Antibodies Available
| Description | Product Code | Applications | Pack Size | List Price | Quantity |
|---|---|---|---|---|---|
| Goat anti Rabbit IgG (Fc):Biotin | STAR121B | E WB | 1 mg |
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| Goat anti Rabbit IgG (Fc):FITC | STAR121F | F | 1 mg |
|
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| Goat anti Rabbit IgG (Fc):HRP | STAR121P | E WB | 1 mg |
|
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| Goat anti Rabbit IgG (H/L):HRP | STAR124P | C E WB | 1 mg |
|
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| Sheep anti Rabbit IgG:FITC | STAR34B | C F | 1 mg |
|
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| Sheep anti Rabbit IgG:RPE | STAR35A | F | 1 ml |
|
|
| Sheep anti Rabbit IgG:DyLight®488 | STAR36D488GA | F IF WB | 0.1 mg | ||
| Sheep anti Rabbit IgG:DyLight®680 | STAR36D680GA | F IF WB | 0.1 mg | ||
| Sheep anti Rabbit IgG:Dylight®800 | STAR36D800GA | F IF WB | 0.1 mg |
