CREB Binding Protein antibody

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Anti CREB Binding Protein Antibody (PrecisionAb Polyclonal Antibody) gallery image 1 — Western blot analysis of whole cell lysates probed with CREB binding protein antibody followed by detection with HRP conjugated Goat anti Rabbit (1/10,000, STAR208P) and visualized on the ChemiDoc MP with 1 second exposure. Arrow points to CREB binding protein (molecular weight 300 kDa)

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Rabbit anti CREB Binding Protein

Product Type: PrecisionAb Polyclonal
Isotype: Polyclonal IgG
Format: Purified
Specificity: CREB Binding Protein

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VPA00303 Datasheet Datasheet SDS SDS	WB	100 µl		Log in	Get Quote
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Rabbit anti Human CREB binding protein antibody recognizes CREB binding protein, also known as CREBBP and CBP.

CREB binding protein is ubiquitously expressed and is involved in the transcriptional co-activation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), CREB binding protein is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by the CREB binding protein gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in the CREB binding protein gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving the CREB binding protein gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms (provided by RefSeq, Feb 2009).

Rabbit anti Human CREB binding protein antibody detects a band of 300 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.

Target Species: Human
Western Blotting: Anti CREB binding protein detects a band of approximately 300 kDa in HEK293 cell lysate.
Species Cross-Reactivity: Target Species Cross Reactivity

Mouse

Rat; N.B. Antibody reactivity and working conditions may vary between species.
Product Form: Purified IgG - liquid
Preparation: Rabbit polyclonal antibody purified by affinity chromatography.
Buffer Solution: Phosphate buffered saline.
Preservative Stabilisers: 0.09% Sodium Azide (NaN₃)
2% Sucrose
Immunogen: Synthetic peptide corresponding to the N-terminal region of human CREB binding protein
Regulatory: For research purposes only.
Guarantee: 12 months from date of despatch.
Acknowledgements: PrecisionAb is a trademark of Bio-Rad Laboratories.

Target Species	Cross Reactivity
Mouse
Rat

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
Western Blotting		1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Description	Product Code	Applications	Pack Size	Your Price
Goat anti Rabbit IgG (H/L):HRP	STAR208P	WB	2 ml	Log in	Get Quote
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Description	Goat anti Rabbit IgG (H/L):HRP

UniProt: Q92793
Entrez Gene: CREBBP
GO Terms: GO:0001666 response to hypoxia; GO:0002039 p53 binding; GO:0003700 sequence-specific DNA binding transcription factor activity; GO:0003713 transcription coactivator activity; GO:0004402 histone acetyltransferase activity; GO:0004871 signal transducer activity; GO:0005737 cytoplasm; GO:0006461 protein complex assembly; GO:0008270 zinc ion binding; View More GO Terms; GO:0016573 histone acetylation; GO:0016604 nuclear body; GO:0018076 N-terminal peptidyl-lysine acetylation; GO:0042592 homeostatic process; GO:0044255 cellular lipid metabolic process; GO:0044419 interspecies interaction between organisms; GO:0051577 MyoD binding