COMT antibody

Rabbit anti COMT

Product Type
PrecisionAb Polyclonal
Isotype
Polyclonal IgG
Format
Purified
Specificity
COMT

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VPA00856
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Rabbit anti Human COMT antibody recognizes COMT, also known as catechol O-methyltransferase.

Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters (provided by RefSeq, Sep 2008).

Rabbit anti Human COMT antibody detects bands of 24 and 28 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Anti COMT antibody recognizes bands of approximately 24 & 28 kDa in HEK293 cell lysates
Product Form
Purified IgG - liquid
Preparation
Rabbit polyclonal antibody purified by affinity chromatography on immunogen
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide
<50% Glycerol
Immunogen
Recombinant protein of human COMT
Regulatory
For research purposes only
Guarantee
12 months from date of despatch
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories

Store undiluted at -20°C, avoiding repeated freeze thaw cycles

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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UniProt
P21964
Entrez Gene
COMT
GO Terms
GO:0005886 plasma membrane
GO:0005515 protein binding
GO:0000287 magnesium ion binding
GO:0042136 neurotransmitter biosynthetic process
GO:0016021 integral to membrane
GO:0005829 cytosol
GO:0005625 soluble fraction
GO:0005792 microsome
GO:0006805 xenobiotic metabolic process
GO:0016206 catechol O-methyltransferase activity
GO:0042135 neurotransmitter catabolic process
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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