Goat anti Human choline acetyl transferase antibody
recognizes Choline acetyl transferase, also known as ChAT. ChAT is a 748 amino acid ~70-80 kDa cytoplasmic protein present in cholinergic neurons in the brain and central nervous system, responsible for the reversible synthesis of acetylcholine from acetyl CoA and choline (Kim et al. 2006
). Three isoforms have been described derived from alternative splicing and differing by alteration or deletion in the N-terminal region.
Mutations in the CHAT gene can lead to the development of Myasthenic syndrome, congenital, 6, presynaptic (CMS6
), an autosomal recessive condition characterized by failure of neuromuscular transmission, not of autoimmune origin. Suffers show variable widespread muscular fatigability worsening with physical effort (Kraner et al. 2003
- Target Species
- Species Cross-Reactivity
|Target Species||Cross Reactivity|
- N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Serum - liquid
- Preservative Stabilisers
- 0.2% Sodium Azide (NaN3)
- Human placental enzyme.
- -20ºC only (ship +4ºC)
- 12 months from date of despatch
- Entrez Gene
- GO Terms
neurotransmitter biosynthetic process
choline O-acetyltransferase activity
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of Choline Acetyltransferase antibody
|Immunohistology - Frozen
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using the appropriate negative/positive controls.
Copyright © 2020 Bio-Rad Antibodies (formerly AbD Serotec)
Secondary Antibodies Available
Product Specific References
References for Choline Acetyltransferase antibody
Ding, J. et al. (2017) Neuroprotection and CD131/GDNF/AKT Pathway of Carbamylated Erythropoietin in Hypoxic Neurons.
Mol Neurobiol. 54 (7): 5051-60.