Choline Acetyltransferase antibody

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Goat anti Human Choline Acetyltransferase

Product Type
Polyclonal Antibody
Polyclonal IgG
Product Code Applications Pack Size List Price Quantity
50 µl

Goat anti Human choline acetyl transferase antibody recognizes Choline acetyl transferase, also known as ChAT. ChAT is a 748 amino acid ~70-80 kDa cytoplasmic protein present in cholinergic neurons in the brain and central nervous system, responsible for the reversible synthesis of acetylcholine from acetyl CoA and choline (Kim et al. 2006). Three isoforms have been described derived from alternative splicing and differing by alteration or deletion in the N-terminal region.

Mutations in the CHAT gene can lead to the development of Myasthenic syndrome, congenital, 6, presynaptic (CMS6), an autosomal recessive condition characterized by failure of neuromuscular transmission, not of autoimmune origin. Suffers show variable widespread muscular fatigability worsening with physical effort (Kraner et al. 2003).

Product Details

Target Species
Species Cross-Reactivity
Target SpeciesCross Reactivity
Guinea Pig
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Serum - liquid
Preservative Stabilisers
0.2% Sodium Azide (NaN3)
Human placental enzyme.

Storage Information

-20ºC only (ship +4ºC)
12 months from date of despatch

More Information

Entrez Gene
GO Terms
GO:0042136 neurotransmitter biosynthetic process
GO:0004102 choline O-acetyltransferase activity
GO:0005829 cytosol
GO:0005634 nucleus
GO:0007269 neurotransmitter secretion
For research purposes only

Applications of Choline Acetyltransferase antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunohistology - Frozen 1/500 1/1000
Western Blotting 1/1000 1/5000
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using the appropriate negative/positive controls.

Secondary Antibodies Available

Description Product Code Applications Pack Size List Price Quantity
Rabbit anti Goat IgG (Fc):FITC STAR122F F 1 mg loader
Rabbit anti Goat IgG (Fc):HRP STAR122P C E WB 1 mg loader

Product Specific References

References for Choline Acetyltransferase antibody

  1. Ding, J. et al. (2017) Neuroprotection and CD131/GDNF/AKT Pathway of Carbamylated Erythropoietin in Hypoxic Neurons.
    Mol Neurobiol. 54 (7): 5051-60.

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