CELF1 antibody

Rabbit anti CELF1

Product Type
PrecisionAb Polyclonal
Isotype
Polyclonal IgG
Format
Purified
Specificity
CELF1

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VPA00386
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Rabbit anti Human CELF1 antibody recognizes the CUGBP Elav-like family member 1, also known as CUG binding protein 1, 50 kDa nuclear polyadenylated RNA-binding protein, bruno-like protein 2, embryo deadenylation element binding protein and nuclear polyadenylated RNA-binding protein, 50 kDa.

Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. CELF1 may play a role in myotonic dystrophy type 1 (DM1) via interactions with the dystrophia myotonica-protein kinase (DMPK) gene. Alternative splicing results in multiple transcript variants encoding different isoforms (provided by RefSeq, Jul 2008).

Rabbit anti Human CELF1 antibody detects a band of 52 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Anti CELF1 detects a band of approximately 52 kDa in HeLa cell lysate
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Preparation
Rabbit polyclonal antibody purified by affinity chromatography.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide (NaN3).
Immunogen
KLH-conjugated synthetic peptide corresponding to aa 1-30 of human CELF1
Regulatory
For research purposes only
Guarantee
12 months from date of despatch.
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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UniProt
Q92879
Entrez Gene
CELF1
GO Terms
GO:0000166 nucleotide binding
GO:0005515 protein binding
GO:0000900 translation repressor activity, nucleic acid binding
GO:0003729 mRNA binding
GO:0030529 ribonucleoprotein complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0006376 mRNA splice site selection
GO:0007281 germ cell development
GO:0009790 embryo development
GO:0016246 RNA interference
GO:0042835 BRE binding
GO:0043484 regulation of RNA splicing
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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