CELF1 antibody
Rabbit anti Human CELF1 antibody recognizes the CUGBP Elav-like family member 1, also known as CUG binding protein 1, 50 kDa nuclear polyadenylated RNA-binding protein, bruno-like protein 2, embryo deadenylation element binding protein and nuclear polyadenylated RNA-binding protein, 50 kDa.
Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. CELF1 may play a role in myotonic dystrophy type 1 (DM1) via interactions with the dystrophia myotonica-protein kinase (DMPK) gene. Alternative splicing results in multiple transcript variants encoding different isoforms (provided by RefSeq, Jul 2008).
Rabbit anti Human CELF1 antibody detects a band of 52 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. CELF1 may play a role in myotonic dystrophy type 1 (DM1) via interactions with the dystrophia myotonica-protein kinase (DMPK) gene. Alternative splicing results in multiple transcript variants encoding different isoforms (provided by RefSeq, Jul 2008).
Rabbit anti Human CELF1 antibody detects a band of 52 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
Product Details
- Target Species
- Human
- Western Blotting
- Anti CELF1 detects a band of approximately 52 kDa in HeLa cell lysate
- Species Cross-Reactivity
-
Target Species Cross Reactivity Mouse - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Preparation
- Rabbit polyclonal antibody purified by affinity chromatography
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Immunogen
- KLH-conjugated synthetic peptide corresponding to aa 1-30 of human CELF1
Storage Information
- Storage
- Store undiluted at -20oC, avoiding repeated freeze thaw cycles
- Guarantee
- 12 months from date of despatch
More Information
- UniProt
- Q92879
- Entrez Gene
- CELF1
- GO Terms
- GO:0000166 nucleotide binding
- GO:0005515 protein binding
- GO:0000900 translation repressor activity, nucleic acid binding
- GO:0003729 mRNA binding
- GO:0030529 ribonucleoprotein complex
- GO:0005634 nucleus
- GO:0005737 cytoplasm
- GO:0006376 mRNA splice site selection
- GO:0007281 germ cell development
- GO:0009790 embryo development
- GO:0016246 RNA interference
- GO:0042835 BRE binding
- GO:0043484 regulation of RNA splicing
- Acknowledgements
- PrecisionAb is a trademark of Bio-Rad Laboratories
- Regulatory
- For research purposes only
Applications of CELF1 antibody
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting | 1/1000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
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Secondary Antibodies Available
| Description | Product Code | Applications | Pack Size | List Price | Quantity |
|---|---|---|---|---|---|
| Goat anti Rabbit IgG (H/L):HRP | STAR208P | WB | 2 ml |
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