Rabbit anti Cdk6 (pTyr13)
recognizes cyclin-dependent kinase 6 (Cdk6) also known as cell division protein kinase 6 or serine/threonine-protein kinase PLSTIRE, when phosphorylated at tyrosine 13. Cdk6 is a member of the serine/threonine protein kinase family and is involved in regulation of cell-cycle progression during G1 phase and transition from G1 to S phase. Phosphorylation of Cdk6 at tyrosine 24 inhibits the kinase activity of Cdk6 (Bertero et al. 2013
- Target Species
- Species Cross-Reactivity
|Target Species||Cross Reactivity|
||Expected from Sequence
- N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antiserum to Cdk6 (pTyr24) was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.02% Sodium Azide
- Phospho specific-peptide corresponding to residues surrounding tyrosine 24 of human Cdk6
- Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
G1 phase of mitotic cell cycle
cyclin-dependent protein kinase holoenzyme complex
positive regulation of cell-matrix adhesion
response to virus
cyclin-dependent protein kinase activity
regulation of gene expression
regulation of erythrocyte differentiation
negative regulation of osteoblast differentiation
negative regulation of cell cycle
positive regulation of fibroblast proliferation
negative regulation of epithelial cell proliferation
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of CDK6 (pTyr24) antibody
|Immunohistology - Paraffin
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Copyright © 2022 Bio-Rad Antibodies (formerly AbD Serotec)
Secondary Antibodies Available
Useful Reagents Available
Product Specific References
Bertero, T. et al. (2013) CDC25A targeting by miR-483-3p decreases CCND-CDK4/6 assembly and contributes to cell cycle arrest.
Cell Death Differ. 20 (6): 800-11.
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