CDK2 (pThr160) antibody
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WB P ResetRabbit anti CDK2 (pThr160)
- Product Type
- Polyclonal Antibody
- Isotype
- Polyclonal IgG
- Specificity
- CDK2 (pThr160)
Antibody Quality and Performance Guarantee
| Rabbit anti Cdk2 (pThr160) antibody recognizes cyclin-dependent kinase 2 (CDK2) also known as cell division protein kinase 2 and p33 protein kinase when phosphorylated at threonine 160. CDK2 belongs to the serine/threonine protein kinase family and CDC2/CDKX sub family and plays a vital role as part of the cell cycle machinery. Threonine 160 and tyrosine 15 are two major phosphorylation sites. Dephosphorylation of threonine 14 and tryrosine 15 and phosphorylation of threonine 160 are required to activate CDK2 (Gu et al. 1992). |
- Target Species
- Human
- Species Cross-Reactivity
-
Target Species Cross Reactivity Mouse Expected from Sequence Rat Expected from Sequence - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antiserum to Cdk2 (pThr160) was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.02% Sodium Azide
50% Glycerol - Immunogen
- Phospho specific-peptide corresponding to residues surrounding threonine 160 of human Cdk2
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Immunohistology - Paraffin |  |
1/50 | 1/100 |
| Western Blotting | |
1/500 | 1/2000 |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
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Further Reading
-
Gu, Y. et al. (1992) Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15.
EMBO J. 11 (11): 3995-4005.
- UniProt
- P24941
- Entrez Gene
- CDK2
- GO Terms
- GO:0006260 DNA replication
- GO:0000082 G1/S transition of mitotic cell cycle
- GO:0000084 S phase of mitotic cell cycle
- GO:0000085 G2 phase of mitotic cell cycle
- GO:0000086 G2/M transition of mitotic cell cycle
- GO:0000216 M/G1 transition of mitotic cell cycle
- GO:0000307 cyclin-dependent protein kinase holoenzyme complex
- GO:0007596 blood coagulation
- GO:0005829 cytosol
- View More GO Terms
- GO:0004693 cyclin-dependent protein kinase activity
- GO:0005524 ATP binding
- GO:0006275 regulation of DNA replication
- GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
- GO:0007067 mitosis
- GO:0007089 traversing start control point of mitotic cell cycle
- GO:0007265 Ras protein signal transduction
- GO:0008284 positive regulation of cell proliferation
- GO:0042802 identical protein binding
- GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
- GO:0051301 cell division
- GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
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