CDC73 antibody

Rabbit anti CDC73

Product Type
PrecisionAb Polyclonal
Isotype
Polyclonal IgG
Format
Purified
Specificity
CDC73

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VPA00622
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Rabbit anti Human CDC73 antibody recognizes parafibromin, also known as also known as Paf1/RNA polymerase II complex component cell division cycle 73, cell division cycle protein 73 homolog, HRPT2 or hyperparathyroidism 2 protein.

CDC73 gene encodes a tumor suppressor that is involved in transcriptional and post-transcriptional control pathways. The protein is a component of the the PAF protein complex, which associates with the RNA polymerase II subunit POLR2A and with a histone methyltransferase complex. This protein appears to facilitate the association of 3' mRNA processing factors with actively-transcribed chromatin. Mutations in CDC73 have been linked to hyperparathyroidism-jaw tumor syndrome, familial isolated hyperparathyroidism, and parathyroid carcinoma (provided by RefSeq, Jul 2009).

Rabbit anti Human CDC73 antibody detects a band of 60 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Rabbit anti CDC73 detects a band of approximately 60 kDa in NIH/3T3 cell lysates.
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
Rat
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Preparation
Rabbit polyclonal antibody purified by affinity chromatography.
Buffer Solution
Phosphate buffered saline.
Preservative Stabilisers
0.09% Sodium Azide
2% Sucrose
Immunogen
Synthetic peptide encompassing part of the middle region of human CDC73
Regulatory
For research purposes only.
Guarantee
12 months from date of despatch.
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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Description Goat anti Rabbit IgG (H/L):HRP

UniProt
Q6P1J9
Entrez Gene
CDC73
GO Terms
GO:0005515 protein binding
GO:0006350 transcription
GO:0007049 cell cycle
GO:0010390 histone monoubiquitination
GO:0016593 Cdc73/Paf1 complex
GO:0033523 histone H2B ubiquitination
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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