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CD262 antibody

Product Code Applications Pack Size List Price Your Price Qty
AHP488
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
C WB 0.1 mg loader
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loader

Rabbit anti Human CD262 antibody recognizes human Tumor necrosis factor receptor superfamily member 10B, also known as CD262, Death receptor 5 or TNF-related apoptosis-inducing ligand receptor 2. CD262 is a 385 amino acid ~60 kDa single pass type ! transmembrane protein acting as a Receptor for the cytotoxic ligand TNFSF10/TRAIL.

Mutations in the TNFRSF10B gene has been implicated in the development of Squamous cell carcinoma of the head and neck (HNSCC) a non melanoma cancer affecting the head and neck.

Target Species
Human
Product Form
Purified IgG - liquid
Antiserum Preparation
Antisera to human CD262 (DR5) were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
Immunogen
Synthetic peptide corresponding to amino acids 388-407 of human CD262 (DR5)
Approx. Protein Concentrations
IgG concentration 0.5mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunohistology - Frozen
Western Blotting 1/500 1/1000
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.

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References for CD262 antibody

  1. Graf, D. et al. (2003) Inhibition of taurolithocholate 3-sulfate-induced apoptosis by cyclic AMP in rat hepatocytes involves protein kinase A-dependent and -independent mechanisms.
    Arch Biochem Biophys. 415 (1): 34-42.

Further Reading

  1. Chaudhary, P.M. et al. (1997) Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway.
    Immunity. 7 (6): 821-30.

Synonyms
DR5
TRAIL-R2
RRID
AB_322894
UniProt
O14763
Entrez Gene
TNFRSF10B
GO Terms
GO:0005886 plasma membrane
GO:0016021 integral to membrane
GO:0004872 receptor activity
GO:0006919 activation of caspase activity
GO:0007166 cell surface receptor linked signaling pathway
GO:0007250 activation of NF-kappaB-inducing kinase activity
GO:0008625 induction of apoptosis via death domain receptors
GO:0008633 activation of pro-apoptotic gene products
GO:0008656 caspase activator activity
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0045569 TRAIL binding

AHP488

080914

If you cannot find the batch/lot you are looking for please contact our technical support team for assistance.

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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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