CD262 antibody


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WB IC ResetRabbit anti Human CD262
- Product Type
- Polyclonal Antibody
- Isotype
- Polyclonal IgG
- Specificity
- CD262
Rabbit anti Human CD262 antibody recognizes human Tumor necrosis factor receptor superfamily member 10B, also known as CD262, Death receptor 5 or TNF-related apoptosis-inducing ligand receptor 2. CD262 is a 385 amino acid ~60 kDa single pass type ! transmembrane protein acting as a Receptor for the cytotoxic ligand TNFSF10/TRAIL. Mutations in the TNFRSF10B gene has been implicated in the development of Squamous cell carcinoma of the head and neck (HNSCC) a non melanoma cancer affecting the head and neck. |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antisera to human CD262 (DR5) were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Immunogen
- Synthetic peptide corresponding to amino acids 388-407 of human CD262 (DR5)
- Approx. Protein Concentrations
- IgG concentration 0.5mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Application Name | Verified | Min Dilution | Max Dilution |
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Immunohistology - Frozen | ![]() |
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Western Blotting | ![]() |
1/500 | 1/1000 |
Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
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Goat anti Rabbit IgG (Fc):Biotin | STAR121B | E WB | 1 mg |
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Description | Goat anti Rabbit IgG (Fc):Biotin | ||||||
Goat anti Rabbit IgG (Fc):FITC | STAR121F | F | 1 mg |
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Description | Goat anti Rabbit IgG (Fc):FITC | ||||||
Goat anti Rabbit IgG (Fc):HRP | STAR121P | E WB | 1 mg |
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Description | Goat anti Rabbit IgG (Fc):HRP | ||||||
Goat anti Rabbit IgG (H/L):HRP | STAR124P | C E WB | 1 mg |
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Description | Goat anti Rabbit IgG (H/L):HRP | ||||||
Sheep anti Rabbit IgG:FITC | STAR34B | C F | 1 mg |
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Description | Sheep anti Rabbit IgG:FITC | ||||||
Sheep anti Rabbit IgG:RPE | STAR35A | F | 1 ml |
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Description | Sheep anti Rabbit IgG:RPE |
Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
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TidyBlot Western Blot Detection Reagent:HRP | STAR209P | WB * | 0.5 ml | Log in | |||
List Price | Your Price | ||||||
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Description | TidyBlot Western Blot Detection Reagent:HRP |
References for CD262 antibody
-
Graf, D. et al. (2003) Inhibition of taurolithocholate 3-sulfate-induced apoptosis by cyclic AMP in rat hepatocytes involves protein kinase A-dependent and -independent mechanisms.
Arch Biochem Biophys. 415 (1): 34-42.
Further Reading
-
Chaudhary, P.M. et al. (1997) Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway.
Immunity. 7 (6): 821-30.
- Synonyms
- DR5
- TRAIL-R2
- RRID
- AB_322894
- UniProt
- O14763
- Entrez Gene
- TNFRSF10B
- GO Terms
- GO:0005886 plasma membrane
- GO:0016021 integral to membrane
- GO:0004872 receptor activity
- GO:0006919 activation of caspase activity
- GO:0007166 cell surface receptor linked signaling pathway
- GO:0007250 activation of NF-kappaB-inducing kinase activity
- GO:0008625 induction of apoptosis via death domain receptors
- GO:0008633 activation of pro-apoptotic gene products
- GO:0008656 caspase activator activity
- View More GO Terms
- GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade
- GO:0045569 TRAIL binding
AHP488

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