CD262 antibody

Goat anti Human CD262

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
CD262

Product Code Applications Pack Size List Price Your Price Qty
AHP1806
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Goat anti Human CD262 antibody recognizes CD262, otherwise known as DR5/TRAIL-R2, a broadly expressed death domain containing receptor and member of the TNF-receptor superfamily, which acts as a mediator for CD253/TRAIL induced apoptosis in a variety of tumor and transformed cells, but not in normal cells. Expression of CD262 is regulated by tumor suppressor p53, and CD262 is highly expressed by tumor cell lines. The death domain containing adaptor protein FADD, is required for CD262-mediated apoptosis, and recruits caspase-8 to the activated receptor. Goat anti Human CD262 antibody is suitable for use in immunocytochemistry.

Target Species
Human
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Antiserum Preparation
Antiserum to human CD262 was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.1% Sodium Azide (NaN3)
0.1% Bovine Serum Albumin
Immunogen
Synthetic peptide APQQKRSSPSEGLCPPGHHISEDGRDC corresponding to amino acids 68-94 of the extracellular domain of human CD262.
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

Store at -20oC only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA 1/75,000
Flow Cytometry
Immunohistology - Paraffin 1/150
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Flow Cytometry
Use 10ul of the suggested working dilution to label 1x106 cells in 100ul.
ELISA
This product is suitable for use in indirect ELISA applications.
Histology Positive Control Tissue
Spleen

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Synonyms
DR5
TRAIL-R2
RRID
AB_2204935
UniProt
O14763
Q9QZM4
Entrez Gene
TNFRSF10B
Tnfrsf10b
GO Terms
GO:0005886 plasma membrane
GO:0016021 integral to membrane
GO:0004872 receptor activity
GO:0006919 activation of caspase activity
GO:0007166 cell surface receptor linked signaling pathway
GO:0007250 activation of NF-kappaB-inducing kinase activity
GO:0008625 induction of apoptosis via death domain receptors
GO:0008633 activation of pro-apoptotic gene products
GO:0008656 caspase activator activity
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0045569 TRAIL binding
View more products with CD262 specificity

Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

View all Anti-Human Products