CD253 antibody
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P WB ResetRabbit anti Human CD253 (C-Terminal)
- Product Type
- Polyclonal Antibody
- Isotype
- Polyclonal IgG
- Specificity
- CD253
- Region
- (C-TERMINAL)
Antibody Quality and Performance Guarantee
| Rabbit anti Human CD253 antibody recognizes the ~32 kDa apoptosis related protein designated TRAIL (TNF-related apoptosis-inducing ligand) CD253 also known as TRAIL. CD253 is a type II membrane protein expressed in a variety of tissues. Receptors for TRAIL have been identified and termed DR4 and DR5 (Griffith and Lynch 1998). |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antisera to CD253 (TRAIL) were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
0.02% Sodium Azide - Immunogen
- Peptide from C-terminus of human CD253 (TRAIL).
- Approx. Protein Concentrations
- IgG concentration 1 mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Immunohistology - Paraffin 1 |  |
||
| Western Blotting | |
1/500 |
- 1 This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose.
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
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Further Reading
-
Wiley, S.R. et al. (1995) Identification and characterization of a new member of the TNF family that induces apoptosis.
Immunity. 3 (6): 673-82. -
Pitti, R.M. et al. (1996) Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family.
J Biol Chem. 271 (22): 12687-90.
- Synonyms
- TRAIL
- RRID
- AB_322739
- UniProt
- P50591
- Entrez Gene
- TNFSF10
- GO Terms
- GO:0007165 signal transduction
- GO:0005887 integral to plasma membrane
- GO:0005125 cytokine activity
- GO:0005164 tumor necrosis factor receptor binding
- GO:0046872 metal ion binding
- GO:0005615 extracellular space
- GO:0005625 soluble fraction
- GO:0006919 activation of caspase activity
- GO:0006955 immune response
- View More GO Terms
- GO:0007267 cell-cell signaling
- GO:0008624 induction of apoptosis by extracellular signals
- GO:0008633 activation of pro-apoptotic gene products
- GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade
AHP440
146282
156213
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