Rabbit anti CD246 / ALK antibody recognizes the CD246 antigen, also known as ALK (anaplastic lymphoma kinase) tyrosine kinase receptor. The ALK kinase domain, upon ligand binding, becomes activated and mediates MAPK signaling pathways via phosphorylating proteins such as MAPK1/ERK2 and MAPK3/ERK1 on tyrosine residues.
- Target Species
- Product Form
- Purified IgG - liquid
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 30% Glycerol
0.5% Bovine Serum Albumin
- Synthetic peptide corresponding to C-terminus of human CD246 / ALK
- Approx. Protein Concentrations
- IgG concentration 0.5 mg/ml
- Store at -20oC
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
transmembrane receptor protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase signaling pathway
integral to plasma membrane
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of CD246 / Alk antibody
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Western Blotting
- Rabbit anti CD246 / ALK antibody recognizes a band of approximately 80 kDa in Jurkat cell lysates
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Secondary Antibodies Available