CD230. also known as the prion protein (PrP) exists in two alternate forms; a normal cellular form (PrPc) and a disease-associated form (PrPSc).The normal and pathological forms of the prion protein have identical amino acid sequences and differ only in their folded tertiary structure and biochemical properties.
Goat anti Human CD230 (N-Terminal) antibody has been shown to stain PrPSc plaques in formalin fixed sections of CJD brain. It also reacts with PrPc.
- Target Species
- Species Cross-Reactivity
Target Species Cross Reactivity Bovine Sheep Hamster
- N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Serum - liquid
- Antiserum Preparation
- Antisera to human PrP27-30 were raised by repeated immunisation of goats with highly purified antigen.
- Preservative Stabilisers
0.1% Sodium Azide
- Synthetic peptide corresponding to amino acids 79-97 of the N-terminus of human prion protein
- Store at +4oC or at -20oC if preferred.
This product should be stored undiluted.
Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- 18 months from date of despatch.
- P04156 Related reagents
- Entrez Gene
- PRNP Related reagents
- For research purposes only
Applications of CD230 antibody
|Application Name||Verified||Min Dilution||Max Dilution|
|Immunohistology - Paraffin||1/200|
- This product does not require protein digestion pre-treatment of paraffin sections.This product does not require antigen retrieval using heat treatment prior to staining of paraffin sections.
- Histology Positive Control Tissue
- CJD brain
Secondary Antibodies Available
|Description||Product Code||Applications||Pack Size||List Price||Quantity|
|Rabbit anti Goat IgG (Fc):FITC||STAR122F||F||1 mg|
|Rabbit anti Goat IgG (Fc):HRP||STAR122P||C E WB||1 mg|
Product Specific References
References for CD230 antibody
Shinagawa, M. et al. (1986) Immunoreactivity of a synthetic pentadecapeptide corresponding to the N-terminal region of the scrapie prion protein.
J Gen Virol. 67 ( Pt 8): 1745-50.
Mao-Draayer, Y.et al. (2002) Emerging patterns of diffusion-weighted MR imaging in Creutzfeldt-Jakob disease: case report and review of the literature.
AJNR Am J Neuroradiol. 23 (4): 550-6.