CD220 antibody
Activation of CD220 leads to a number of cellular effects, including glucose uptake, the regulation of cell proliferation and gene expression. These effects mostly occur in skeletal muscle, fat and the liver. Neuronal CD220 signalling has been shown to have an important role in energy homeostasis, reproduction and the development of neurodegenerative diseases.
Product Details
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antisera to CD220 were raised by repeated immunisations of rabbit with highly purified antigen. Purified IgG prepared by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
0.09% Sodium Azide (NaN3) - Immunogen
- Synthetic peptide corresponding to human CD220 - conjugated to KLH.
- Approx. Protein Concentrations
- IgG concentration 0.1mg/ml
Storage Information
- Storage
- Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. - Guarantee
- 12 months from date of despatch
More Information
- UniProt
- P06213
- Entrez Gene
- INSR
- GO Terms
- GO:0000187 activation of MAPK activity
- GO:0001934 positive regulation of protein phosphorylation
- GO:0003007 heart morphogenesis
- GO:0004716 receptor signaling protein tyrosine kinase activity
- GO:0005009 insulin receptor activity
- GO:0005159 insulin-like growth factor receptor binding
- GO:0046872 metal ion binding
- GO:0005524 ATP binding
- GO:0005525 GTP binding
- GO:0005792 microsome
- GO:0005899 insulin receptor complex
- GO:0005901 caveola
- GO:0005975 carbohydrate metabolic process
- GO:0007186 G-protein coupled receptor protein signaling pathway
- GO:0008284 positive regulation of cell proliferation
- GO:0008543 fibroblast growth factor receptor signaling pathway
- GO:0010008 endosome membrane
- GO:0046326 positive regulation of glucose import
- GO:0018108 peptidyl-tyrosine phosphorylation
- GO:0019087 transformation of host cell by virus
- GO:0030335 positive regulation of cell migration
- GO:0031994 insulin-like growth factor I binding
- GO:0031995 insulin-like growth factor II binding
- GO:0032148 activation of protein kinase B activity
- GO:0032583 regulation of gene-specific transcription
- GO:0042169 SH2 domain binding
- GO:0042593 glucose homeostasis
- GO:0043410 positive regulation of MAPKKK cascade
- GO:0043548 phosphatidylinositol 3-kinase binding
- GO:0043559 insulin binding
- GO:0043560 insulin receptor substrate binding
- GO:0045429 positive regulation of nitric oxide biosynthetic process
- GO:0045725 positive regulation of glycogen biosynthetic process
- GO:0045740 positive regulation of DNA replication
- GO:0045821 positive regulation of glycolysis
- GO:0045840 positive regulation of mitosis
- GO:0045995 regulation of embryonic development
- GO:0046777 protein autophosphorylation
- GO:0048639 positive regulation of developmental growth
- GO:0051290 protein heterotetramerization
- GO:0051425 PTB domain binding
- GO:0051897 positive regulation of protein kinase B signaling cascade
- GO:0060267 positive regulation of respiratory burst
- Regulatory
- For research purposes only
Applications of CD220 antibody
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
Immunohistology - Paraffin 1 | 5 | 15ug/ml |
- 1This product requires antigen retrieval using heat treatment prior to staining of paraffin sections.Sodium citrate buffer pH 6.0 is recommended for this purpose.
- Histology Positive Control Tissue
- Pancreas, Islet of Langerhans
Secondary Antibodies Available
Description | Product Code | Applications | Pack Size | List Price | Quantity |
---|---|---|---|---|---|
Goat anti Rabbit IgG (Fc):Biotin | STAR121B | E WB | 1 mg |
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Goat anti Rabbit IgG (Fc):FITC | STAR121F | F | 1 mg |
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|
Goat anti Rabbit IgG (Fc):HRP | STAR121P | E WB | 1 mg |
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|
Goat anti Rabbit IgG (H/L):HRP | STAR124P | C E WB | 1 mg |
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|
Sheep anti Rabbit IgG:FITC | STAR34B | C F | 1 mg |
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Sheep anti Rabbit IgG:RPE | STAR35A | F | 1 ml |
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Sheep anti Rabbit IgG:DyLight®488 | STAR36D488GA | F IF WB | 0.1 mg | ||
Sheep anti Rabbit IgG:DyLight®680 | STAR36D680GA | F IF WB | 0.1 mg | ||
Sheep anti Rabbit IgG:Dylight®800 | STAR36D800GA | F IF WB | 0.1 mg |
Useful Reagents Available
Description | Product Code | Applications | Pack Size | List Price | Quantity |
---|---|---|---|---|---|
Antigen Retrieval Buffer, pH8.0 | BUF025A | P | 500 ml | ||
100x Antigen Retrieval Buffer, pH8.0 | BUF025C | P | 50 ml | ||
Histar Detection System | STAR3000A | C P | 50 Tests |
Product Specific References
References for CD220 antibody
-
Youngren, J.F. (2007) Regulation of insulin receptor function.
Cell Mol Life Sci. 64 (7-8): 873-91. -
Wada, A. et al. (2005) New twist on neuronal insulin receptor signaling in health, disease, and therapeutics.
J Pharmacol Sci. 99 (2): 128-43. -
Toth, B. et al. (2009) Insulin and leptin receptors as possible new candidates for endocrine control in normal and disturbed human pregnancy.
Mol Hum Reprod. 15 (4): 231-9.
Further Reading
-
Plum, L. et al. (2005) The role of insulin receptor signaling in the brain.
Trends Endocrinol Metab. 16 (2): 59-65.
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