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CD193 antibody

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Anti Human CD193 Antibody thumbnail image 1 Anti Human CD193 Antibody thumbnail image 2
Anti Human CD193 Antibody gallery image 1
Western blot analysis on normal human spleen lysate probed with Rabbit anti Human CD193 (AHP1010)
Anti Human CD193 Antibody gallery image 2
Formalin fixed, paraffin embedded normal human spleen stained with Rabbit anti Human CD193 (AHP1010) following heat mediated antigen retrieval using sodium citrate buffer (pH6.0).

Rabbit anti Human CD193

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
CD193

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Product Code Applications Pack Size List Price Your Price Qty
AHP1010
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
C IF P * WB 0.1 mg loader
List Price Your Price
loader

Rabbit anti Human CD193 antibody recognizes human CD193, otherwise known as CC chemokine receptor 3 (CCR3), a seven-helix transmembrane G-protein coupled receptor which, along with CCR5 and CXCR4, acts as a principal receptor for the fusion and entry of HIV into target cells. CD193 is expressed by eosinophils, basophils, mast cells, microglia, Th2 helper cells and some epithelial cells.

CD193 acts as a receptor for several CC chemokines including monocyte chemoattractant proteins (MCP) -1, -2, -3 and -4, MIP-1a, MIP-1β, and RANTES. The eotaxin subgroup of CC chemokines act as specific agonists for CD193 involved in infection of microglia by HIV (He et al. 1997) and allergic reactions (Holse et al. 2006).

Rabbit anti Human CD193 antibody has been used successfully for the detection of human CD193 by immunohistochemistry on formalin fixed, paraffin embedded intervertebral disc tissue (Gruber et al. 2014).

Target Species
Human
Species Cross-Reactivity
Target SpeciesCross Reactivity
Rat
Mouse
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Antiserum Preparation
Antisera to human CD193 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.02%Sodium Azide (NaN3)
Immunogen
Synthetic peptide corresponding to a 14 amino acid sequence located near human CD193 carboxy-terminus.
Approx. Protein Concentrations
IgG concentration 1 mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunofluorescence
Immunohistology - Frozen
Immunohistology - Paraffin 1 10ug/ml
Western Blotting 1ug/ml
  1. 1This product requires antigen retrieval using heat treatment prior to staining of paraffin sections.Sodium citrate buffer pH 6.0 is recommended for this purpose.
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Histology Positive Control Tissue
Human spleen.
Western Blotting
AHP1010 detects a band of approximately 55kDa in human spleen cell lysates (predicted Mwt. 41kDa)

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References for CD193 antibody

  1. Wainwright, D.A. et al. (2009) Exacerbation of facial motoneuron loss after facial nerve axotomy in CCR3-deficient mice.
    ASN Neuro. 1 (5): e00024.
  2. Kallankari, H. et al. (2010) Chemokine CCL18 predicts intraventricular hemorrhage in very preterm infants.
    Ann Med. 42: 416-25.
  3. Mäkikallio, K. et al. (2012) Umbilical artery chemokine CCL16 is associated with preterm preeclampsia and fetal growth restriction.
    Cytokine. 60 (2): 377-84.
  4. Gruber, H.E. et al. (2014) Production and expression of RANTES (CCL5) by human disc cells and modulation by IL-1-β and TNF-α in 3D culture.
    Exp Mol Pathol. 96: 133-8.

Further Reading

  1. Combadiere, C. et al. (1996) Cloning and functional expression of a human eosinophil CC chemokine receptor.
    J Biol Chem. 271 (18): 11034.
  2. He, J. et al. (1997) CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia.
    Nature. 385 (6617): 645-9.
  3. Holse, M. et al. (2006) CCR3, CCR5, CCR8 and CXCR3 expression in memory T helper cells from allergic rhinitis patients, asymptomatically sensitized and healthy individuals.
    Clin Mol Allergy. 4: 6.

Immunofluorescence

Immunohistology - Frozen

Synonyms
CCR3
RRID
AB_2074377
UniProt
P51677
Entrez Gene
CCR3
GO Terms
GO:0007155 cell adhesion
GO:0005887 integral to plasma membrane
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0006968 cellular defense response
GO:0007188 G-protein signaling, coupled to cAMP nucleotide second messenger
GO:0007204 elevation of cytosolic calcium ion concentration
GO:0044419 interspecies interaction between organisms
GO:0045766 positive regulation of angiogenesis

AHP1010

151090 160215

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