CD192 antibody
Goat anti Human CD192 antibody (AHP1810) used to assess CCR2 expression in rat spinal cord tissue by western blotting.
Image caption:
Expression and localization of CCR2 after spinal cord injury. (A, B) Western blotting detection of CCR2 expression in spinal cord tissue.
From: Rong Y, Ji C, Wang Z, Ge X, Wang J, Ye W, Tang P, Jiang D, Fan J, Yin G, Liu W, Cai W.
Small extracellular vesicles encapsulating CCL2 from activated astrocytes induce microglial activation and neuronal apoptosis after traumatic spinal cord injury.
J Neuroinflammation. 2021 Sep 12;18(1):196.
doi: 10.1186/s12974-021-02268-y.
This image is from an open access article distributed under terms of a Creative Commons Attribution License.
Filter by Application:
P ResetGoat anti Human CD192 (N-Terminal)
- Product Type
- Polyclonal Antibody
- Isotype
- Polyclonal IgG
- Specificity
- CD192
- Region
- (N-TERMINAL)
Antibody Quality and 
Unrivaled 
| Goat anti Human CD192 antibody recognizes an epitope within the N-terminal (NT) region of human CD192, otherwise known as CCR2 (C-C chemokine receptor type 2), a transmembrane glycoprotein and member of the G-protein coupled receptor 1 family, which acts as a receptor for the chemokines MCP-1 (monocyte chemoattractant protein 1), MCP-3 and MCP-4. Interaction between CD192 and MCP-1 initiates chemotactic responses, through an increase in intracellular calcium levels. CD192 acts as a co-receptor with CD4 for HIV1 infection, and variations in CD192 are associated with relative resistance to HIV1. |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Antiserum Preparation
- Antiserum to human CD192 (NT) was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography.
- Buffer Solution
- Phosphate buffered saline.
- Preservative Stabilisers
- 0.1% Sodium Azide (NaN3)
0.1% Bovine Serum Albumin - Immunogen
- Synthetic peptide C-GEEVTTFFDYDYGAPCHKFDVKQ corresponding to amino acids 17-39 within the N-terminal region of human CD192.
- Approx. Protein Concentrations
- IgG concentration 1.0mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA |  |
1/30000 | |
| Immunohistology - Paraffin | |
1/100 | |
| Western Blotting | |
1/500 |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- ELISA
- This product is suitable for use in indirect ELISA applications.
- Histology Positive Control Tissue
- Spleen.
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| Rabbit anti Goat IgG (Fc):FITC | STAR122F | F | 1 mg |
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| Antigen Retrieval Buffer, pH8.0 | BUF025A | P | 500 ml | Log in | |||
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| Description | Antigen Retrieval Buffer, pH8.0 | ||||||
References for CD192 antibody
-
Rong, Y. et al. (2021) Small extracellular vesicles encapsulating CCL2 from activated astrocytes induce microglial activation and neuronal apoptosis after traumatic spinal cord injury.
J Neuroinflammation. 18 (1): 196.
- Synonyms
- CCR2
- RRID
- AB_2106272
- UniProt
- P41597
- Entrez Gene
- CCR2
- GO Terms
- GO:0005887 integral to plasma membrane
- GO:0005625 soluble fraction
- GO:0005737 cytoplasm
- GO:0006935 chemotaxis
- GO:0006954 inflammatory response
- GO:0006955 immune response
- GO:0006968 cellular defense response
- GO:0007194 negative regulation of adenylate cyclase activity
- GO:0007204 elevation of cytosolic calcium ion concentration
- View More GO Terms
- GO:0007259 JAK-STAT cascade
- GO:0016493 C-C chemokine receptor activity
- GO:0019221 cytokine-mediated signaling pathway
- GO:0031727 CCR2 chemokine receptor binding
- GO:0044419 interspecies interaction between organisms
View more products with CD192 specificity
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