CD192 antibody

Goat anti Human CD192 (N-Terminal)

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
CD192
Region
(N-TERMINAL)

Product Code Applications Pack Size List Price Your Price Qty
AHP1810
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
E P WB 0.1 mg loader
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Search for Batch Specific Datasheets

Goat anti Human CD192 antibody recognizes an epitope within the N-terminal (NT) region of human CD192, otherwise known as CCR2 (C-C chemokine receptor type 2), a transmembrane glycoprotein and member of the G-protein coupled receptor 1 family, which acts as a receptor for the chemokines MCP-1 (monocyte chemoattractant protein 1), MCP-3 and MCP-4.

Interaction between CD192 and MCP-1 initiates chemotactic responses, through an increase in intracellular calcium levels. CD192 acts as a co-receptor with CD4 for HIV1 infection, and variations in CD192 are associated with relative resistance to HIV1.

Target Species
Human
Product Form
Purified IgG - liquid
Antiserum Preparation
Antiserum to human CD192 (NT) was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography.
Buffer Solution
Phosphate buffered saline.
Preservative Stabilisers
0.1% Sodium Azide (NaN3)
0.1% Bovine Serum Albumin
Immunogen
Synthetic peptide C-GEEVTTFFDYDYGAPCHKFDVKQ corresponding to amino acids 17-39 within the N-terminal region of human CD192.
Approx. Protein Concentrations
IgG concentration 1.0mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA 1/30000
Immunohistology - Paraffin 1/100
Western Blotting 1/500
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
ELISA
This product is suitable for use in indirect ELISA applications.
Histology Positive Control Tissue
Spleen.

Description Product Code Applications Pack Size List Price Your Price Quantity
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Description Rabbit anti Goat IgG (Fc):FITC
Rabbit anti Goat IgG (Fc):HRP STAR122P C E WB 1 mg loader
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Description Rabbit anti Goat IgG (Fc):HRP

Description Product Code Applications Pack Size List Price Your Price Quantity
Antigen Retrieval Buffer, pH8.0 BUF025A P 500 ml
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Description Antigen Retrieval Buffer, pH8.0

References for CD192 antibody

  1. Rong, Y. et al. (2021) Small extracellular vesicles encapsulating CCL2 from activated astrocytes induce microglial activation and neuronal apoptosis after traumatic spinal cord injury.
    J Neuroinflammation. 18 (1): 196.

Synonyms
CCR2
RRID
AB_2106272
UniProt
P41597
Entrez Gene
CCR2
GO Terms
GO:0005887 integral to plasma membrane
GO:0005625 soluble fraction
GO:0005737 cytoplasm
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0006968 cellular defense response
GO:0007194 negative regulation of adenylate cyclase activity
GO:0007204 elevation of cytosolic calcium ion concentration
GO:0007259 JAK-STAT cascade
GO:0016493 C-C chemokine receptor activity
GO:0019221 cytokine-mediated signaling pathway
GO:0031727 CCR2 chemokine receptor binding
GO:0044419 interspecies interaction between organisms
View more products with CD192 specificity

Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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