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CD184 / CXCR4 antibody

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Anti Human CD184 / CXCR4 Antibody thumbnail image 1
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Paraffin embedded human spleen stained with Goat anti Human CD184 / CXCR4 (AHP1808).

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Goat anti Human CD184 / CXCR4

Product Type
Polyclonal Antibody
Isotype
Polyclonal IgG
Specificity
CD184 / CXCR4
Region
(N-TERMINAL)

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Product Code Applications Pack Size List Price Your Price Qty
AHP1808
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
E P WB 0.1 mg loader
List Price Your Price
loader

Goat anti Human CD184 / CXCR4 antibody recognizes an epitope within the N-terminal (NT) region of human CD184, otherwise known as CXCR4 (C-X-C chemokine receptor type 4), a transmembrane glycoprotein and member of the G-protein coupled receptor 1 family, ubiquitously expressed in blood and tissue cells, which acts as a specific receptor for the chemokine SDF-1 (Stromal cell-derived factor 1).

Interaction of CD184 with SDF-1 mediates the chemotaxis of progenitor and mature blood cells, and is critical for B- lymphopoiesis and myelopoiesis. CD184 is a major co-receptor for infection by T-cell tropic strains of HIV1, and also a primary receptor for some HIV2 isolates.

Goat anti Human CD184 / CXCR4 antibody is being suitable for use in immunofluorescence.

Target Species
Human
Species Cross-Reactivity
Target SpeciesCross Reactivity
Rat
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Antiserum Preparation
Antiserum to human CD184 / CXCR4 (NT) was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography.
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.1% Sodium Azide (NaN3)
0.1% Bovine Serum Albumin
Immunogen
Synthetic peptide TEEMGSGDYDSMKEPCFREENANFNKC corresponding to amino acids 17-43 within the N-terminal region of human CD184 / CXCR4.
Approx. Protein Concentrations
IgG concentration 1.0mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA 1/25000
Immunohistology - Paraffin 1/150
Western Blotting 1/250
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Histology Positive Control Tissue
Spleen

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RRID
AB_2089655
UniProt
P61073
O08565
Entrez Gene
Cxcr4
CXCR4
GO Terms
GO:0005886 plasma membrane
GO:0001764 neuron migration
GO:0002064 epithelial cell development
GO:0016021 integral to membrane
GO:0005768 endosome
GO:0008038 neuron recognition
GO:0016493 C-C chemokine receptor activity
GO:0016494 C-X-C chemokine receptor activity
GO:0022029 telencephalon cell migration
GO:0043067 regulation of programmed cell death
GO:0050920 regulation of chemotaxis
GO:0051924 regulation of calcium ion transport
GO:0060048 cardiac muscle contraction
GO:0000187 activation of MAPK activity
GO:0001666 response to hypoxia
GO:0003779 actin binding
GO:0009615 response to virus
GO:0006915 apoptosis
GO:0006954 inflammatory response
GO:0007204 elevation of cytosolic calcium ion concentration
GO:0009986 cell surface
GO:0015026 coreceptor activity
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0019059 initiation of viral infection
GO:0030260 entry into host cell
GO:0031252 cell leading edge
GO:0031625 ubiquitin protein ligase binding
GO:0032027 myosin light chain binding
GO:0043130 ubiquitin binding

AHP1808

151104

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